{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:43:36Z","timestamp":1784126616014,"version":"3.55.0"},"reference-count":38,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Purpose:<\/i><\/b> To evaluate exercise-induced changes in ocular blood flow (OBF) parameters in primary open-angle glaucoma (POAG) patients. <b><i>Methods:<\/i><\/b> A prospective observational study was carried out, in which medically treated patients with POAG were enrolled. Following inclusion, all patients performed a 40-min cycloergometry in a standardized fashion. The following parameters were measured and compared immediately before and 1 and 30 min after the exercise: intraocular pressure (IOP; Goldman applanation tonometry), mean arterial pressure (MAP), ocular pulse amplitude (OPA; assessed by dynamic contour tonometry), and ocular perfusion pressure (OPP; 2\/3 MAP \u2013 IOP). In addition, we investigated possible factors associated with OBF parameter changes immediately after exercise. <b><i>Results:<\/i><\/b> A total of 30 eyes (30 patients; mean age was 62.9 \u00b1 1.7 years) were included. Most patients were women (53%), and median visual field mean deviation index was \u20133.5 dB. Both MAP (mean change, 21%) and IOP (mean change, 17.3%) increased significantly immediately after the workout (<i>p<\/i> &#x3c; 0.01), persisting higher than baseline following 30 min (<i>p<\/i> &#x3c; 0.01%). Regarding OBF parameters, both OPA (mean change, 58.8%) and OPP (mean change, 21.7%) increased significantly immediately after the workout and persisted higher than baseline 30 min after the workout (<i>p<\/i> &#x3c; 0.01). Regression analysis revealed that only age was significantly associated with OPA variation (<i>R<\/i><sup>2<\/sup> 0.14; <i>p<\/i> &#x3c; 0.05). No significant associations were found for OPP (<i>p<\/i> \u2265 0.19). <b><i>Conclusion:<\/i><\/b> Aerobic exercise leads to a significant short-time increase in OBF parameters in patients with POAG. Even though IOP seems to present a modest elevation, it is accompanied by a significant increase in MAP, leading to higher OBF measurements. Exercise-induced short-term changes and its possible implications for glaucoma prognosis deserve further investigation.<\/jats:p>","DOI":"10.1159\/000501694","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T21:00:35Z","timestamp":1567630835000},"page":"309-313","source":"Crossref","is-referenced-by-count":13,"title":["Exercise-Induced Changes in Ocular Blood Flow Parameters in Primary Open-Angle Glaucoma 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