{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:48:01Z","timestamp":1781106481807,"version":"3.54.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Acute kidney injury (AKI) and intraventricular hemorrhage (IVH) are common in premature infants. We previously demonstrated that infants with AKI have a higher hazards ratio to develop grade \u22652 IVH when controlling for confounders. However, that single-center study was unable to show an overall association. <b><i>Objectives:<\/i><\/b> To test the hypothesis that infants diagnosed with AKI have an increased risk of IVH independent of variables associated with both AKI and IVH, we performed a study on 825 infants from the Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) study (a 24-center multinational retrospective cohort). <b><i>Method:<\/i><\/b> A neonatal modified KDIGO definition of AKI was used based on serum creatinine (SCr) and\/or urine output criteria. Baseline SCr was defined as the lowest previous value. IVH was diagnosed with head ultrasounds. <b><i>Results:<\/i><\/b> AKI was documented in 22.2% (183\/825) of infants and IVH in 14.3% (118\/825). Infants with AKI (<i>n<\/i> = 183) were more likely to have IVH (26.8%, 49\/183) than those without AKI (<i>n<\/i>= 642) who had IVH (10.7%, 69\/642, <i>p<\/i> &#x3c; 0.0001). After controlling for 5-min Apgar score, vasopressor support within the first week of age, and gestational age, infants with AKI had 1.6 times higher adjusted odds to develop any grade IVH (95% CI 1.04\u20132.56). Furthermore, infants of gestational age of 22\u201328 weeks had 1.9 times higher adjusted odds to develop IVH (OR 1.87, 95% CI 1.08\u20133.23). <b><i>Conclusions:<\/i><\/b> We present the first multicenter evaluation of the association between AKI and IVH in premature infants showing a significant independent association between AKI and IVH. Development of strategies to reduce AKI may also reduce IVH.<\/jats:p>","DOI":"10.1159\/000501708","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T21:00:34Z","timestamp":1568235634000},"page":"321-330","source":"Crossref","is-referenced-by-count":49,"title":["The Association of Intraventricular Hemorrhage and Acute Kidney Injury in Premature Infants from the Assessment of the Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) Study"],"prefix":"10.1159","volume":"116","author":[{"given":"Christine","family":"Stoops","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Boohaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Sims","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0T.","family":"Selewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Askenazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on\u00a0behalf\u00a0of\u00a0the\u00a0National\u00a0Kidney\u00a0Collaborative\u00a0(NKC)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1977-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1133-x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(17)30069-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05190514"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3819"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.230"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12984"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0221"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-9091(98)80030-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198505233122104"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.09.007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2009.01.011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214237"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64767-0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000445931"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2016.00068"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32834f62d5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198307283090402"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4847.134674"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)81109-9"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2008.07.014"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:44:18Z","timestamp":1745423058000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000501708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,11,27]]},"published-print":{"date-parts":[[2019,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000501708","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}