{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:42:23Z","timestamp":1779345743431,"version":"3.51.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Radiation-induced thyroid dysfunction following oncologic treatment is not uncommon, however limited literature data has been found on patients that underwent chemotherapy only. A change in thyrometabolic autoimmune status is also a rare entity. We present a case of newly diagnosed Graves\u2019 thyrotoxicosis following a successful R-CHOP (Rituximab, Cyclophosphamide, Doxorubicine, Vincristine and Prednisone) treatment in a patient with concurrent abdominal and thyroid diffuse large B-cell lymphoma (DLBCL). Following chemotherapy, PET CT showed resolution of FDG-avid thyroid nodule as well as no evidence of the thyroid mass on repeat ultrasound. Her thyroid function also normalized. During her follow-up visit, patient reported significant unintentional weight loss and persistent fatigue over the past couple months. Repeat laboratory evaluation revealed TSH 0.005 mIU\/mL, FT4 6.73 ng\/dL and thyroid stimulating immunoglobulin (TSI) 535 (ref &amp;#x3c;140%). She was started on methimazole followed by radioactive iodine therapy. This unique case of Graves\u2019 disease following R-CHOP treatment in patients with known Hashimoto\u2019s and thyroid lymphoma is one of the first to be reported in the literature. The swing of pendulum from Hashimoto\u2019s to Graves\u2019 disease is very uncommon. As clinicians, we need to continue monitoring for clinical and biochemical thyroid dysfunction in this subset of population.<\/jats:p>","DOI":"10.1159\/000501714","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T21:00:35Z","timestamp":1564002035000},"page":"581-588","source":"Crossref","is-referenced-by-count":4,"title":["R-CHOP-Associated Graves\u2019 Hyperthyroidism"],"prefix":"10.1159","volume":"12","author":[{"given":"Natalie","family":"Mora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine\u00a0N.","family":"Vu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7437-5604","authenticated-orcid":false,"given":"Thanh\u00a0D.","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinh\u00a0Q.","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed\u00a0K.M.","family":"Shakir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/9.suppl_5.S133"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108293250902"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-1-91"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13044-016-0030-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K10E-166"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/182176"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050565"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181ef72a1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e3283330848"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.17925\/EE.2008.04.02.107"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.116"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12427"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.15226\/2374-6890\/3\/1\/00143"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4158\/EP171785.CR"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:44:23Z","timestamp":1745423063000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000501714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,24]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,9,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000501714","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,24]]}}}