{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:09Z","timestamp":1787017929422,"version":"build-2736575974"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Middle cerebral artery (MCA) pulsatility index (PI) Doppler in the third trimester of pregnancy is increasingly used. <b><i>Objectives:<\/i><\/b> The aim of the study was to investigate intra- and interobserver reproducibility of MCA PI in the third trimester. <b><i>Method:<\/i><\/b> Singleton pregnancies between 30<sup>+0<\/sup> and 40<sup>+0<\/sup> weeks were recruited. MCA Doppler velocimetry measurements were performed prospectively, independently, and blindly. Intra- and interobserver reproducibility was assessed by concordance correlation coefficient (CCC) and intraclass correlation coefficient (ICC); Bland-Altman plots were built, and limits of agreement (LoA) were calculated. Results were interpreted according to the cutoff set by the True Reproducibility of Ultrasound Techniques Review. <b><i>Results:<\/i><\/b> We enrolled 101 patients. ICCs for intraobserver reproducibility were 0.84 and 0.78 for raw values and percentiles, respectively; CCCs were 0.72 and 0.64. For interobserver reproducibility ICCs were 0.84 and 0.78, CCCs 0.72 and 0.63. According to the chosen criteria, these values show a poor-moderate reproducibility of third trimester MCA PI. Cohen\u2019s Kappa coefficients were 0.59 and 0.42, indicating a moderate agreement in discriminating normal and abnormal values. <b><i>Conclusions:<\/i><\/b> Intra- and interobserver reproducibility of third trimester MCA PI, as assessed by ICC, CCC, and LoA, is far from satisfactory. This should be taken into account before taking clinical decisions.<\/jats:p>","DOI":"10.1159\/000501772","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T17:00:33Z","timestamp":1569258033000},"page":"214-219","source":"Crossref","is-referenced-by-count":10,"title":["Intra- and Interobserver Reproducibility of Third Trimester Middle Cerebral Artery Pulsatility Index Measurement: A Prospective Cross-Sectional Study"],"prefix":"10.1159","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6733-7658","authenticated-orcid":false,"given":"Lucia","family":"Pasquini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Marchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Gaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Mecacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina\u00a0Maddalena","family":"Bilardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6249"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15729"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14654"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12371"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1868"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1108"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00079.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00652.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31820b0884"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.05.028"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031497"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14714"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14647"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.10.013"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.10.024"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.11.016"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.5.837"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.05.008"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18830"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17500"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62049-3"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20102"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2816"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.002"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13320"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14729"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:45:12Z","timestamp":1745408712000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000501772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,3]]},"published-print":{"date-parts":[[2020,3,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000501772","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,21]]}}}