{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:33:21Z","timestamp":1770741201171,"version":"3.49.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> High arterial oxygen saturation (SaO<sub>2<\/sub>) is associated with the development of retinopathy of prematurity (ROP), but difficult to avoid. <b><i>Objective:<\/i><\/b> To assess the association between severe ROP and a burden of cerebral and arterial hyperoxia. <b><i>Methods:<\/i><\/b> We retrospectively analyzed 225 preterm infants born \u226430 weeks\u2019 gestation. The cerebral oxygen saturation (r<sub>c<\/sub>SO<sub>2<\/sub>) and SaO<sub>2<\/sub> were measured within the first 96 h after birth. We determined the burden of both cerebral and arterial hyperoxia, which was defined as the percentage of time spent at saturation thresholds exceeding 85 and 90%, respectively. Their association with severe ROP (prethreshold disease type 1) was tested using logistic regression analyses. <b><i>Results:<\/i><\/b> Median gestational age (GA) was 28.0 weeks (interquartile range 26.7\u201329.0) and mean birth weight 1,032 g (\u00b1281 SD). Eight infants developed severe ROP. Infants with severe ROP spent more time at cerebral hyperoxic levels than infants without severe ROP (medians 30 vs. 16%). Adjusted for GA, for every 10% increase in burden of cerebral hyperoxia, the OR for developing ROP was 1.50 (95% CI 1.09 \u2013 2.06, <i>p<\/i> = 0.013). A burden of arterial hyperoxia was not associated with ROP. Infants with severe ROP experienced even less arterial hyperoxia, although not statistically significant. <b><i>Conclusions:<\/i><\/b> Cerebral hyperoxia may be a better early predictor of severe ROP than arterial hyperoxia. Moreover, under strict oxygen management, cerebral hyperoxia in these infants may result from cerebral immaturity rather than a high SaO<sub>2<\/sub>. Whether reducing cerebral hyperoxia is feasible and might prevent ROP needs to be further examined.<\/jats:p>","DOI":"10.1159\/000501859","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T21:00:33Z","timestamp":1567717233000},"page":"356-362","source":"Crossref","is-referenced-by-count":11,"title":["Postnatal Cerebral Hyperoxia Is Associated with an Increased Risk of Severe Retinopathy of Prematurity"],"prefix":"10.1159","volume":"116","author":[{"given":"Anne\u00a0E.","family":"Richter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arend\u00a0F.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.\u00a0Angela","family":"Huiskamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth\u00a0M.W.","family":"Kooi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.02.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000444901"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.280"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011190.pub2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000351346"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148077"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.227"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00201.2016"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.186"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.01.010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.06.055"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12622"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1684"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.131"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000151642"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173440"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.133"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.5555"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.5725"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2004.03.030"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.1.e61"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7635"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308829"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:46:12Z","timestamp":1745423172000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000501859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,11,27]]},"published-print":{"date-parts":[[2019,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000501859","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}