{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:13:49Z","timestamp":1791724429769,"version":"4.3.4"},"reference-count":49,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of this work was to define a differential marker profile for pregnancy complications near delivery. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We enrolled pregnant women who were referred to the outpatient pregnancy clinic of the University Medical Center, Ljubljana, Slovenia, due to symptoms of pregnancy complications and women with a history of pregnancy complications attending the high-risk hospital clinic for close surveillance. They were evaluated for prior risk and were tested for biophysical and biochemical markers at the time of enrolment. Biochemical markers included the pro- and anti-angiogenic markers, along with additional previously reported markers of potential value, all tested by various formats of immuno-diagnostics. Biophysical markers included blood pressure, sonographic markers, and EndoPAT. Statistical differences were determined with Kruskal-Wallis and Mann-Whitney tests for continuous parameters, and Pearson \u03c7&lt;sup&gt;2&lt;\/sup&gt; for categorical values. &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05 was considered significant. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The cohort included 125 pregnant patients, 31 developed preeclampsia (PE) alone (13 were &amp;#x3c;34 weeks\u2019 gestation), 16 had intrauterine growth restriction (IUGR) alone (12 were &amp;#x3c;34 weeks), 42 had both IUGR and PE (22 were &amp;#x3c;34 weeks), and 15 had an iatrogenic preterm delivery (PTD; 6 were &amp;#x3c;34 weeks). Twenty-one were unaffected and delivered a healthy baby at term. Mean arterial blood pressure and proteinuria were significantly higher in PE and PE+IUGR but not in pure IUGR or PTD. In PE, IUGR, and PE+IUGR, the levels of soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) were significantly higher, while placental growth factor (PlGF) was very low compared to unaffected controls and PTD. PE, IUGR, and PE+IUGR also had a high anti-angiogenic ratio (sFlt-1\/PlGF) and a low proangiogenic ratio of PlGF\/(sFlt-1+Eng). Levels of inhibin A were significantly higher in pure PE across subgroups but had many extreme values, which made it a poor differentiator. Higher uterine artery Doppler pulsatility indexes were detected in PE, IUGR, and PE+IUGR, with similar resistance indexes and peaks of systolic velocity. A significantly different marker level between PE and IUGR was found using arterial stiffness that was 10 times higher in PE; concurrently with an increase of the reactive hyperemia index, both were accompanied by a slight increase in placental protein 13. Higher tumor necrosis factor alpha (TNF\u03b1) differentially identified iatrogenic very early PTD (&amp;#x3c;34 weeks). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Arterial stiffness can serve as a major marker to differentiate PE (with\/without IUGR) from pure IUGR near delivery. TNF\u03b1 can differentiate iatrogenic early PTD from other complications of pregnancy and term IUGR.<\/jats:p>","DOI":"10.1159\/000502177","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T22:00:33Z","timestamp":1574978433000},"page":"471-484","source":"Crossref","is-referenced-by-count":9,"title":["Establishing a Differential Marker Profile for Pregnancy Complications Near 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