{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:16:57Z","timestamp":1788959817655,"version":"build-2803163510"},"reference-count":10,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Noninvasive ventilation is recommended for neonatal respiratory distress to avoid adverse effects of invasive ventilation. <b><i>Objective:<\/i><\/b> The aim of this study was to compare the feasibility of noninvasive neurally adjusted ventilatory assist (NIV NAVA) and continuous positive airway pressure (CPAP) in preterm newborn infants. <b><i>Methods:<\/i><\/b> Forty preterm infants (gestational age 28+0 to 36+6 weeks) requiring CPAP and supplemental oxygen (FiO<sub>2<\/sub> &#x3e;0.23) for respiratory distress at &#x3c;48 h of postnatal age were randomized to NIV NAVA or CPAP. The primary endpoint was the inspired oxygen concentration 12 h after study inclusion. Secondary endpoints were the duration of oxygen treatment, total duration of respiratory support, parenteral nutrition, blood gas values, patient comfort, need for invasive ventilation, and treatment complications. <b><i>Results:<\/i><\/b> The mean FiO<sub>2<\/sub> at the time of study inclusion was 0.29 in both groups. After 12 h of treatment, FiO<sub>2<\/sub> was 0.26 \u00b1 0.07 and 0.26 \u00b1 0.04 in the NIV NAVA and CPAP groups, respectively (difference 0.006, 95% CI \u20130.4 to 0.5), with no difference between the groups during the course of noninvasive ventilation (<i>p<\/i> = 0.80). Seven patients (35%) in the NIV NAVA group and 10 (50%) in the control group required intubation (difference 15%, 95% CI \u201315.5 to 4.3, <i>p<\/i> = 0.36). Time to intubation, gas exchange, vital parameters, pain scale, treatment complications, and neonatal outcome did not differ between the groups. <b><i>Conclusions:<\/i><\/b> In the present trial, NIV NAVA had no statistically significant effect on oxygen requirements or the need for invasive ventilation in preterm newborn infants.<\/jats:p>","DOI":"10.1159\/000502341","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T21:00:33Z","timestamp":1567717233000},"page":"380-384","source":"Crossref","is-referenced-by-count":34,"title":["NIV NAVA versus Nasal CPAP in Premature Infants: A Randomized Clinical Trial"],"prefix":"10.1159","volume":"116","author":[{"given":"Merja","family":"Kallio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Mahlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Koskela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Aikio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Suo-Palosaari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tytti","family":"Pokka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Saarela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Hallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000499361"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000431074"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.136"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-308057"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1596053"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2014.04.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.157.2.3840268"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2758-y"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-315051"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3985"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:50:47Z","timestamp":1745423447000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000502341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,11,27]]},"published-print":{"date-parts":[[2019,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000502341","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.9771620","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}