{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:31:39Z","timestamp":1777343499002,"version":"3.51.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Aims:<\/i><\/b> The aims of this study were to measure changes in fibroblast growth factor 23 (FGF-23), neutrophil (elastase, lactoferrin)\/platelet activation marker (mean platelet volume-to-platelet count ratio [MPR]), and angiogenin according to the stage of chronic kidney disease (CKD), and to evaluate the association of FGF-23, elastase, lactoferrin, MPR, and angiogenin with arterial stiffness using brachial-ankle pulse wave velocity (ba-PWV) in CKD patients. <b><i>Methods:<\/i><\/b> According to the estimated glomerular filtration rate (eGFR) calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, the patients were allocated to five groups: (1) normal controls (eGFR \u226590 mL\/min\/1.73 m<sup>2<\/sup> without pathologic, urine [proteinuria], blood [electrolyte], and imaging abnormalities; <i>n<\/i> = 22); (2) CKD stage 2 (eGFR 60\u201389 mL\/min\/1.73 m<sup>2<\/sup>; <i>n<\/i> = 17); (3) CKD stage 3 (eGFR 30\u201359 mL\/min\/1.73 m<sup>2<\/sup>; <i>n<\/i> = 22); (4) CKD stage 4 (eGFR 15\u201330 mL\/min\/1.73 m<sup>2<\/sup>; <i>n<\/i> = 17); and (5) CKD stage 5-hemodialysis (HD) (<i>n<\/i> = 30). All the patients were free of clinically apparent cardiovascular disease. Serum FGF-23, elastase, lactoferrin, and angiogenin concentrations and the MPR were measured to study the association of the above parameters with the clinical (age, sex, presence of diabetes mellitus, and blood pressure), biochemical (calcium, phosphorus, uric acid, intact parathyroid hormone [PTH], low-density lipoprotein cholesterol, and high-sensitivity C-reactive protein), and ba-PWV values of the CKD patients. <b><i>Results:<\/i><\/b> (1) The mean ba-PWV values were 1,497.2 \u00b1 206.4 cm\/s in the controls, 1,649.0 \u00b1 247.9 cm\/s in the CKD stage 2 group (<i>p<\/i> &#x3c; 0.05 vs. controls), 1,655.8 \u00b1 260.3 cm\/s in the CKD stage 3 group (<i>p<\/i> &#x3c; 0.05 vs. controls), 1,823.0 \u00b1 402.4 cm\/s in the CKD stage 4 group (<i>p<\/i> &#x3c; 0.05 vs. controls and CKD stages 2 and 3), and 1,905.2 \u00b1 374.1 cm\/s in the CKD stage 5-HD group (<i>p<\/i> &#x3c; 0.05 vs. controls and CKD stage 2). (2) The mean log<sub>10<\/sub>(FGF-23) concentration values were 0.77 \u00b1 0.27, 0.97 \u00b1 0.48, 1.10 \u00b1 0.35 (<i>p<\/i> &#x3c; 0.05 vs. controls and CKD stage 2), 1.35 \u00b1 0.48 (<i>p<\/i> &#x3c; 0.05 vs. controls and CKD stages 2 and 3), and 2.12 \u00b1 0.82 (<i>p<\/i> &#x3c; 0.05 vs. controls and CKD stages 2\u20134); the mean angiogenin levels were 230.6 \u00b1 70.5 pg\/mL, 283.0 \u00b1 53.5 pg\/mL (<i>p<\/i> &#x3c; 0.05 vs. controls), 347.3 \u00b1 76.9 pg\/mL (<i>p<\/i> &#x3c; 0.05 vs. controls and CKD stage 2), 445.9 \u00b1 90.6 pg\/mL (<i>p<\/i> &#x3c; 0.05 vs. controls and CKD stages 2 and 3), and 370.9 \u00b1 142.4 pg\/mL (<i>p<\/i> &#x3c; 0.05 vs. controls and CKD stages 2 and 3). (3) In the stage 3\u20134 CKD\/HD patients, the mean elastase-to-neutrophil and lactoferrin-to-neutrophil ratios were significantly lower than in the controls and the stage 2 CKD patients. (4) Our multivariate linear regression analyses showed that age, pulse pressure, mean arterial pressure, PTH, and FGF-23 were independently associated with ba-PWV values. <b><i>Conclusions:<\/i><\/b> Circulating FGF-23 and angiogenin concentrations gradually increased as CKD advanced, whereas neutrophil activation markers were significantly lower in the stage 3\u20134 CKD\/HD patients than in the controls and stage 2 CKD patients. FGF-23 was weakly associated with ba-PWV values in patients with CKD\/HD and no previous cardiovascular disease.<\/jats:p>","DOI":"10.1159\/000502526","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T21:00:56Z","timestamp":1569445256000},"page":"1166-1178","source":"Crossref","is-referenced-by-count":15,"title":["Changes in FGF-23, Neutrophil\/Platelet Activation Markers, and Angiogenin in Advanced Chronic Kidney Disease and Their Effect on Arterial Stiffness"],"prefix":"10.1159","volume":"44","author":[{"given":"Hye-Min","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Eun","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sol","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Jin","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2014.02.009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178939"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg414"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000492244"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140222"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.6.1425"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2010.03162.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000142147"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.6.508"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.09.010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e31828218e7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5551\/jat.10.253"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005010052"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr316"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.01.016"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.01.001"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060658"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00070.2017"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2011.04.006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01995.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00098"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/srep40229"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:52:32Z","timestamp":1745423552000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000502526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,11,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000502526","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}