{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:34:22Z","timestamp":1790825662134,"version":"4.1.0"},"reference-count":8,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Secondary syphilis is a sexually transmitted infection, which is referred to as \u201cthe great imitator\u201d and has a wide spectrum of clinical manifestations. As a result, it is essential to identify potential secondary syphilis patients with ambiguous clinical manifestation through pathology. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We sought to analyze the pathological features of secondary syphilis. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We analyzed 59 biopsy specimens from 56 patients with secondary syphilis. Cases were classified according to the histological characteristics and clinical features. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Necrotic keratinocytes could be observed in 39 of 59 (66.1%) secondary specimens. Plasma cells (86.4%) were the most common finding overall. The presence of &lt;i&gt;Treponema pallidum&lt;\/i&gt; was detected mostly at the dermal-epidermal junction. There was no statistical significance between pathological features and age, HIV status, or RPR titer. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Necrotic keratinocytes are one of the characteristics of secondary syphilis. The combination of plasma cells, irregular acanthosis, elongated rete ridges, and endothelial swelling should increase the likelihood of syphilis.<\/jats:p>","DOI":"10.1159\/000502641","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T17:00:32Z","timestamp":1568912432000},"page":"145-150","source":"Crossref","is-referenced-by-count":30,"title":["Histologic Features of Secondary Syphilis"],"prefix":"10.1159","volume":"236","author":[{"given":"Xiao\u00a0Ke","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4820-5251","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143304"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1969.01610280089017"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1987.tb00537.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1969.01610190076014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/095646249100200411"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.10.017"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1975.tb06476.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.062"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:53:45Z","timestamp":1745409225000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000502641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,19]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,4,29]]},"published-print":{"date-parts":[[2020,4,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000502641","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.9879368","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,19]]}}}