{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T15:23:44Z","timestamp":1771860224896,"version":"3.50.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Introduction:<\/i><\/b> This study aimed to assess the association between antenatal corticosteroid (ACS) and in-hospital outcomes of preterm singleton appropriate for gestational age (AGA) infants according to the presence of maternal histologic chorioamnionitis (HCA). <b><i>Methods:<\/i><\/b> A retrospective study was performed with singleton AGA neonates of 23<sup>+0<\/sup> to 33<sup>+6<\/sup> weeks\u2019 gestation born between 2007 and 2014. We compared the clinical outcomes according to the presence of HCA and ACS use. We also divided the ACS group into 2 groups: infants who received ACS 2\u20137 days before birth (optimal ACS) or not (suboptimal ACS). Multivariate logistic regression with Firth\u2019s penalized likelihood was performed. <b><i>Results:<\/i><\/b> In total, 254 neonates were eligible with 109 neonates with HCA (42.9%). In multivariate analysis adjusting for GA, sex, and cesarean section, ACS use was associated with reduced severe bronchopulmonary dysplasia (BPD) or death and hypotension within 7 postnatal days among the neonates with HCA. However, it was associated with increased patent ductus arteriosus (PDA) treatment. In the optimal ACS group, severe BPD or death (aOR 0.03, 95% CI 0.01\u20130.42), hypotension (aOR 0.02, 95% CI 0.01\u20130.26), and inhaled nitric oxide use (aOR 0.06, 95% CI 0.00\u20130.81) were lower, however, PDA treatment (aOR 8.14, 95% CI 1.20\u201355.24) and sepsis (aOR 6.85, 95% CI 1.02\u201346.07) were higher when compared with the no ACS group among HCA+ infants. Among HCA\u2013 infants, only PDA treatment was lower in the ACS group. <b><i>Conclusion:<\/i><\/b> In neonates with HCA, ACS treatment was associated with reduced morbidities. However, increased sepsis was associated with optimal ACS use.<\/jats:p>","DOI":"10.1159\/000502650","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T21:00:32Z","timestamp":1570568432000},"page":"369-375","source":"Crossref","is-referenced-by-count":18,"title":["The Associations between Antenatal Corticosteroids and In-Hospital Outcomes of Preterm Singleton Appropriate for Gestational Age Neonates according to the Presence of Maternal Histologic Chorioamnionitis"],"prefix":"10.1159","volume":"116","author":[{"given":"Young\u00a0Hye","family":"Ryu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohee","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,10,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002237"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004454.pub3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02751.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-3106-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000499361"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000320170"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.05.019"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000339577"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/srep37967"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138114"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.05.020"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181b7c4da"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1598246"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.2.e6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13723"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3762-6"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:53:49Z","timestamp":1745423629000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000502650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,11,27]]},"published-print":{"date-parts":[[2019,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000502650","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.9948878","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}