{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:38:14Z","timestamp":1780090694458,"version":"3.54.0"},"reference-count":37,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>Background: Perivascular adipose tissue (PVAT) reduces vascular tone in isolated arteries in vitro, however there are no studies of PVAT effects on vascular tone in vivo. In vitro adipocyte \u03b23-adrenoceptors play a role in PVAT function via secretion of the vasodilator adiponectin. Objective: We have investigated the effects of PVAT on vessel diameter in vivo, and the contributions of \u03b23-adrenoceptors and adiponectin. Method: In anaesthetised rats, sections of the intact mesenteric bed were visualised and the diameter of arteries was recorded. Arteries were stimulated with electrical field stimulation (EFS), noradrenaline (NA), arginine-vasopressin (AVP), and acetylcholine (Ach). Results: We report that in vivo, stimulation of PVAT with EFS, NA, and AVP evokes a local anti-constrictive effect on the artery, whilst PVAT exerts a pro-contractile effect on arteries subjected to Ach. The anti-constrictive effect of PVAT stimulated with EFS and NA was significantly reduced using \u03b23-adrenoceptor inhibition, and activation of \u03b23-adrenoceptors potentiated the anti-constrictive effect of vessels stimulated with EFS, NA, and AVP. The \u03b23-adrenoceptor agonist had no effect on mesenteric arteries with PVAT removed. A blocking peptide for adiponectin receptor 1 polyclonal antibody reduced the PVAT anti-constrictive effect in arteries stimulated with EFS and NA, indicating that adiponectin may be the anti-constrictive factor released upon \u03b23-adrenoceptor activation. Conclusions: These results clearly demonstrate that PVAT plays a paracrine role in regulating local vascular tone in vivo, and therefore may contribute to the modulation of blood pressure. This effect is mediated via adipocyte \u03b23-adrenoceptors, which may trigger release of the vasodilator adiponectin.<\/jats:p>","DOI":"10.1159\/000502689","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T00:57:13Z","timestamp":1569632233000},"page":"320-332","source":"Crossref","is-referenced-by-count":18,"title":["Perivascular Adipose Tissue Contributes to the Modulation of Vascular Tone in vivo"],"prefix":"10.1159","volume":"56","author":[{"given":"Sophie\u00a0N.","family":"Saxton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah\u00a0B.","family":"Withers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Nyvad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Mazur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Matchkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9043-2119","authenticated-orcid":false,"given":"Anthony\u00a0M.","family":"Heagerty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Aalkj\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2012.663928"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/490650"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110151"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.821181"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.1415"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.02.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt560"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/0003319715584126"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000443885"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307210"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/srep44571"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.310777"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2007.00764.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0255"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2174\/138161207781039634"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.10.005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500088R"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1113\/JP274604"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05997.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14433"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3109\/10641969109042063"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.05.028"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00697.2012"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.09.026"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0817-1"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301476"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.04.074"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.05.025"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303031"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2337\/dbi17-0016"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13619"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.03.004"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.5.1126"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.98"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-1039"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1603"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803793"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/jvr\/article-pdf\/56\/6\/320\/3907940\/000502689.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/jvr\/article-pdf\/56\/6\/320\/3907940\/000502689.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:54:07Z","timestamp":1745423647000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000502689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,12,12]]},"published-print":{"date-parts":[[2019,12,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000502689","archive":["Portico"],"relation":{},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"value":"1018-1172","type":"print"},{"value":"1423-0135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}