{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:21:50Z","timestamp":1754194910744,"version":"3.40.5"},"reference-count":21,"publisher":"S. Karger AG","issue":"11","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Histologic transformation (HT) of indolent B-cell lymphomas into an aggressive form can occur simultaneously (primary HT, pHT) or sequentially after a preceding diagnosis of indolent lymphoma (secondary HT, sHT). The clinical course after diagnosis of HT is variable. <b><i>Objectives:<\/i><\/b> To describe the outcome of treatment in pHT and sHT patients. <b><i>Methods:<\/i><\/b> We retrospectively analyzed HT cases with an underlying follicular lymphoma, nodal marginal zone lymphoma, extranodal marginal zone lymphoma, lymphoplasmacytic lymphoma, or small lymphocytic lymphoma at our institution. Kaplan-Meier estimates were used to calculate progression-free survival (PFS) and overall survival (OS). <b><i>Results:<\/i><\/b> Ninety-two HT patients were identified, 38 with pHT and 54 with sHT. In sHT, time-to-transformation was not influenced by the preceding treatment strategy of the indolent lymphoma component. In pHT, median PFS was 61 months (95% CI 27\u201361), and OS was not reached. In sHT, median PFS and OS was 14 months (95% CI 9\u201332) and 42 months (95% CI 16\u201390), respectively. Significant differences between pHT and sHT in PFS (<i>p<\/i> = 0.002; Hazard ratio [HR] 2.30, 95% CI 1.36\u20133.91) and OS (<i>p<\/i> = 0.0001; HR 3.30, 95% CI 1.81\u20136.03) were observed. Response to treatment for transformation was highly prognostic of PFS and OS (<i>p<\/i> &#x3c; 0.0001). <b><i>Conclusions:<\/i><\/b> The outcome in pHT cases is favorable and signifi\u00adcantly better than in sHT cases. Failure to achieve a remission after treatment for transformation confers a dismal pro\u00adgnosis.<\/jats:p>","DOI":"10.1159\/000502754","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T21:00:32Z","timestamp":1568926832000},"page":"580-588","source":"Crossref","is-referenced-by-count":5,"title":["Treatment Outcome in Patients with Primary or Secondary Transformed Indolent B-Cell Lymphomas"],"prefix":"10.1159","volume":"42","author":[{"given":"Sedat","family":"Demirdas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Hense","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"D\u00fchrsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-3873","authenticated-orcid":false,"given":"Andreas","family":"H\u00fcttmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1200\/JCO.2010.32.7577"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1182\/blood-2014-04-516815"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1007\/s00277-017-3151-2"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1002\/gcc.1150"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1038\/labinvest.3780308"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1080\/10428190410001711479"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1177\/1066896911405656"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1200\/JCO.1997.15.4.1587"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1182\/blood-2015-01-621375"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1200\/JCO.2008.16.0283"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1111\/bjh.15816"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1182\/asheducation-2009.1.532"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1200\/JCO.1999.17.4.1244"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1200\/JCO.2006.09.2403"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1200\/JCO.2006.07.5671"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1200\/JCO.2017.76.8093"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1007\/s00277-018-3578-0"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1093\/annonc\/mdx407"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1200\/JCO.2015.65.7163"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1111\/j.1365-2141.2012.09054.x"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1200\/JCO.2012.48.3990"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:54:43Z","timestamp":1745423683000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000502754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":21,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,18]]},"published-print":{"date-parts":[[2019,11,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000502754","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"type":"print","value":"2296-5270"},{"type":"electronic","value":"2296-5262"}],"subject":[],"published":{"date-parts":[[2019]]}}}