{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T05:49:58Z","timestamp":1769752198026,"version":"3.49.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"12","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; In elderly patients with chronic myeloid leukemia (CML) responsive to imatinib, the incidence of clinically significant (CS) late chronic anemia is still unknown. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; To highlight this issue, we revised retrospectively 81 CML patients aged &amp;#x3e;60 years treated at our Institution with front-line imatinib for at least 24 months in durable complete cytogenetic response (CCyR). CS late chronic anemia was defined as the presence of persistent (&amp;#x3e;6 months) and otherwise unexplained Hb levels \u226410 g\/dL, which occurred &amp;#x3e;6 months from imatinib start. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A condition of CS late chronic anemia occurred in 22 out of 81 patients (27.2%) at different intervals from imatinib start. Seven out of 22 patients (31.8%) needed packed red cell transfusions during the follow-up. At diagnosis, patients who developed CS late chronic anemia were significantly older and had a lower Hb median level. Six out of 22 patients with CS late chronic anemia received subcutaneous recombinant alpha-erythropoietin (EPO) at the standard dosage of 40,000 IU weekly: all 6 patients achieved an erythroid response. A significantly worse event-free survival (EFS) in patients with untreated CS late chronic anemia was observed (&lt;i&gt;p&lt;\/i&gt; = 0.012). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; CS late chronic anemia during long-term treatment with imatinib is a common complication in responsive elderly patients, with worse EFS if untreated. Results with EPO are encouraging, but larger studies are warranted to define its role.<\/jats:p>","DOI":"10.1159\/000502801","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T21:00:32Z","timestamp":1570568432000},"page":"660-664","source":"Crossref","is-referenced-by-count":4,"title":["Incidence of Clinically Significant (\u226410 g\/dL) Late Anemia in Elderly Patients with Newly Diagnosed Chronic Myeloid Leukemia Treated with Imatinib"],"prefix":"10.1159","volume":"42","author":[{"given":"Laura","family":"Cesini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Carmosino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Breccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"De\u00a0Benedittis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u00a0Lucia","family":"De\u00a0Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioia","family":"Colafigli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Molica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Scalzulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvio","family":"Massaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Mariggi\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u00a0Giovanna","family":"Loglisci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u00a0Cristina","family":"Scamuffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Vozella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Diverio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana","family":"Alimena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Fo\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-862X","authenticated-orcid":false,"given":"Roberto","family":"Latagliata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,10,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.253"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.7146"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-324228"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.06.020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23879"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-0092"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-150680"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404983"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.104"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.104"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq715"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3375-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.023101"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11863"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0069"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2006.01645.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2015.12.001"}],"container-title":["Oncology 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