{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:23:37Z","timestamp":1790713417718,"version":"4.1.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; In the first trimester, ultrasound confirmation of normal or abnormal cardiac anatomy is difficult. B-mode and colour flow Doppler (CFD) are used to assess the foetal heart. Superb microvascular imaging (SMI) can visualise blood flow within the heart and vessels in early gestation. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We report an initial experience of SMI for visualisation of normal and abnormal cardiac anatomy in the first trimester. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Transabdominal foetal echocardiography was performed between 11 + 6 and 14 + 3 weeks (Aplio 500 US system, Toshiba Medical Systems, Tokyo, Japan) from January 2017 to December 2017. All scans were performed at a tertiary foetal cardiology unit. To assess the potential utility of the technique for early gestation screening, normal scans were reviewed by foetal medicine trainees with respect to the B-mode, CFD and SMI. Three key views were selected to compare modalities: the 4-chamber view, outflow tracts and the 3-vessel and trachea view (VTV). Visualisation rates of key echocardiographic features of significant cardiac abnormalities by SMI were reviewed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Fifty-five normal echocardiograms and 34 cardiac abnormalities were included. In the normal heart, when B-mode, CFD and SMI were assessed separately, SMI had the highest rate of visualisation of 4-chamber, outflow tracts and 3-VTV (93, 85 and 83%, respectively). Intra-observer reliability was moderate for SMI of the 3 standard views (kappa 1, 0.64 and 0.64); inter-observer for 4-chamber and outflow tract views was moderate (kappa 0.64 and 0.77). In 29\/34 abnormal cases, SMI showed key features, enhancing greyscale visualisation. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; SMI has potential to become a useful, complementary modality for early foetal echocardiography. Further prospective studies are warranted to establish the place of the technique in assessment of the first trimester foetal heart.<\/jats:p>","DOI":"10.1159\/000502839","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T21:00:28Z","timestamp":1570654828000},"page":"268-276","source":"Crossref","is-referenced-by-count":13,"title":["Initial Experience of Superb Microvascular Imaging for Key Cardiac Views in Foetal Assessment before 15 Weeks Gestation"],"prefix":"10.1159","volume":"47","author":[{"given":"Salma","family":"Jabak\u00a0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha\u00a0V.","family":"Vigneswaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta","family":"Charakida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3894-9089","authenticated-orcid":false,"given":"Taner","family":"Kasapoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jader","family":"de\u00a0Jesus\u00a0Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vita","family":"Zidere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00733.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1063"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.05.086"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12517"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.03.017"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1278206"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-017-0241-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2017.10.006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i43.7765"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006862"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.895415"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15866"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.4.585"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502839","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/502839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:55:17Z","timestamp":1745423717000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000502839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,9]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,7]]},"published-print":{"date-parts":[[2020,4,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000502839","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.9959273","asserted-by":"subject"}]},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,9]]}}}