{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:35:19Z","timestamp":1785386119670,"version":"3.55.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Central diabetes insipidus (CDI) is a frequent complication of pituitary surgery, but its diagnosis lacks standardized criteria. Copeptin, a surrogate marker of arginine vasopressin release, is triggered by psycho-physical stresses such as pituitary surgery. Low postoperative copeptin could predict CDI onset. The aims of this study were the validation of copeptin as a predictor of post-neurosurgical CDI and the identification of the optimal timing for its determination. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Sixty-six consecutive patients operated for a hypothalamic-pituitary lesion were evaluated. Copeptin was determined preoperatively and at 1, 6, 12, 24 and 48 h post-extubation. Fifty-eight patients were reassessed after 3\u20136 months post-surgery to confirm transient (3 cases) or permanent CDI (5 cases) diagnosis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A marked copeptin peak was identified at 1 h after extubation, when a value below or equal to 12.8 pmol\/L had a good accuracy in identifying CDI cases (AUC 0.866, 95% CI 0.751\u20130.941). Moreover, a copeptin peak above 4.2 pmol\/L excluded permanent forms (AUC 1, 95% CI 0.629\u20131). Regression analysis identified copeptin as the only significant predictor of CDI (OR 0.86, 95% CI 0.75\u20130.98, &lt;i&gt;p&lt;\/i&gt; = 0.02). A copeptin T1\/T0 ratio below or equal to 1.47 identified patients at risk of isolated biochemical alterations even in the absence of an overt CDI. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; A prompt increase of copeptin is expected at 1 h after extubation. The absence of this peak is a reliable predictor of post-neurosurgical CDI.<\/jats:p>","DOI":"10.1159\/000503145","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T21:00:33Z","timestamp":1567717233000},"page":"525-534","source":"Crossref","is-referenced-by-count":45,"title":["Early Copeptin Determination Allows Prompt Diagnosis of Post-Neurosurgical Central Diabetes Insipidus"],"prefix":"10.1159","volume":"110","author":[{"given":"Alessandro\u00a0Maria","family":"Berton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Penner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Varaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzia","family":"Prencipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rumbolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Settanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Gasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Ghigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Zenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Grottoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1385"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-015-0703-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.endonu.2014.01.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.3.0448"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000311063.10745.D8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-012-0453-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.08.009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-006-9276-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1981"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00121"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0559"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.060038"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12645"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4507"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4527"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13866"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2118"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:58:29Z","timestamp":1745423909000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000503145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,5]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,5,19]]},"published-print":{"date-parts":[[2020,5,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000503145","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,5]]}}}