{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:14:00Z","timestamp":1789053240742,"version":"build-2803163510"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To investigate the changes of serum cystatin C (Cys-C), beta 2-microglobulin (\u03b22-MG), urinary neutrophil gelatinase-associated lipocalin (NGAL), and alpha 1-microglobulin (\u03b11-MG) in asphyxiated neonates, and to evaluate the value of combined detection of multiple biomarkers in the early diagnosis of acute kidney injury (AKI) in asphyxiated neonates. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 110 full-term asphyxiated and 30 healthy neonates were included. The asphyxia neonates were divided into AKI and non-AKI groups. Serum Cys-C, \u03b22-MG, urine NGAL, and \u03b11-MG were measured 24 h after birth. The diagnostic value of the biomarkers was determined using receiver operating characteristic (ROC) curves. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; There was no significant difference in serum creatinine and blood urea nitrogen among the control group, moderate asphyxia group, and severe asphyxia group at 24 h after birth. Significant differences were noticed in terms of serum Cys-C, \u03b22-MG, urinary NGAL, and \u03b11-MG among the 3 groups. Moreover, with the aggravation of asphyxia, the above indicators gradually increased. There were significant differences in the 4 indicators between the AKI and non-AKI groups (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). The area under the ROC curve of the above indicators was 0.670, 0.689, 0.865, and 0.617, respectively (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). The sensitivity and specificity of the combined diagnosis of asphyxia neonatorum AKI with the 4 indicators were 0.974 and 0.506, respectively. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Serum Cys-C, \u03b22-MG, urine NGAL, and \u03b11-MG are early specific indicators for the diagnosis of renal injury after neonatal asphyxia. Combined detection of these parameters could aid clinical evaluation of renal injury in asphyxiated neonates.<\/jats:p>","DOI":"10.1159\/000503555","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T21:00:32Z","timestamp":1569013232000},"page":"285-291","source":"Crossref","is-referenced-by-count":25,"title":["Evaluation of Novel Biomarkers for Early Diagnosis of Acute Kidney Injury in Asphyxiated Full-Term Newborns: A Case-Control Study"],"prefix":"10.1159","volume":"29","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wujuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.062554"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80023-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2008.01.011"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00869128"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000213898"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e318271f4a5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.11.042"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivx198"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-013-1068-x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.051"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-018-3221-z"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2016.12.006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3704-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.3.253"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12054"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-1060-2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/cc5713"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002729"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2162-4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/cc9014"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.04.013"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000326753"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2013.09.004"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2524-6"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182275164"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:01:25Z","timestamp":1745424085000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000503555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,5,29]]},"published-print":{"date-parts":[[2020,6,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000503555","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,20]]}}}