{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:16:34Z","timestamp":1784891794355,"version":"3.55.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"9-10","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objective:<\/i><\/b> This research was aimed to explore protective effects of allicin on rat model of myocardial infarction via JNK signaling pathway. <b><i>Methods:<\/i><\/b> Rat myocardial ischemia model was established with subcutaneous injection of isoproterenol (ISO). Seventy-five rats were randomly divided into 5 groups (<i>n<\/i> = 15): sham group, ISO group, low-dose group (1.2 mg\/kg\/days for 7 days), medium-dose group (1.8 mg\/kg\/days for 7 days), and high-dose group (3.6 mg\/kg\/days for 7 days). Routine HE staining and Masson staining were performed to observe myocardial histopathology. The expression of oxidative stress-related indicators, heart tissue apoptosis-related proteins, and JNK and p-JNK proteins were measured for different groups. <b><i>Results:<\/i><\/b> Compared with the sham group, the T wave value of the ISO group was significantly increased (<i>p &#x3c;<\/i> 0.01). When allicin was administered, the T wave values at different time points in all groups were all decreased. Compared with the sham group, the ratio of eNOS, Bcl-2\/Bax was significantly decreased, and p-eNOS, iNOS, caspase-3, caspase-9, and Cyt-c were significantly elevated in the ISO group (<i>p &#x3c;<\/i> 0.05). After allicin was administered, significant changes in these proteins were observed in the medium- and high-dose groups. There was no significant change in the expression of JNK protein in the ISO group compared with the sham group; however, the expression of eNOS and p-JNK protein were significantly upregulated (<i>p &#x3c;<\/i> 0.01) and the expression of p-eNOS and iNOS were significantly downregulated (<i>p &#x3c;<\/i> 0.01). When allicin was administered, expression of p-JNK protein was significantly downregulated. <b><i>Conclusion:<\/i><\/b> Allicin can reduce oxidative stress damage and cardiomyocyte apoptosis in rat model of myocardial infarction and can significantly regulate JNK signaling pathway. <\/jats:p>","DOI":"10.1159\/000503755","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T21:00:37Z","timestamp":1597266037000},"page":"505-513","source":"Crossref","is-referenced-by-count":18,"title":["Protective Effects of Allicin on ISO-Induced Rat Model of Myocardial Infarction via JNK Signaling Pathway"],"prefix":"10.1159","volume":"105","author":[{"given":"Wen","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-ze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-fen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-na","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00053"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311449"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/2047487317744363"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173963"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.02.022"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.03.016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000475640"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2016.03.010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-016-2523-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/434692"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.08.029"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-7061(00)01298-x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.09.027"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.11.004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-321"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1126-9"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000430271"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2014.10.019"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5651"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/and.12692"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2010.550894"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01210.2007"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.01.010"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.04.008"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.5.2671"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/378684"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:03:25Z","timestamp":1745424205000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000503755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":26,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2020,10,9]]},"published-print":{"date-parts":[[2020,10,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000503755","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}