{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:14:28Z","timestamp":1780992868014,"version":"3.54.1"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Appendage Disord"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>Gefitinib is a multi-target tyrosine kinase inhibitor used for the treatment of non-small cell lung cancer. Papulo-pustular and\/or paronychia, abnormalities in hair growth, itching, and dryness due to epidermal growth factor inhibitors \u2013 i.e., PRIDE Complex \u2013 are a common effect of tyrosine kinase inhibitors. We report a case of hair and eyebrow hyperpigmentation after 7 months of treatment with gefitinib. In the literature, we found no data regarding rapid pigmentation of hair due to treatment with any multi-target tyrosine kinase inhibitors. To our knowledge, this is the first case reporting both hair and eyebrow hyperpigmentation. We hypothesize the role of different mechanisms linked to rapid hair hyperpigmentation.<\/jats:p>","DOI":"10.1159\/000503758","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T21:00:34Z","timestamp":1572037234000},"page":"44-47","source":"Crossref","is-referenced-by-count":5,"title":["The Dark Side of Gefitinib: Reflectance Confocal Microscopy Applied to Hair Hyperpigmentation"],"prefix":"10.1159","volume":"6","author":[{"given":"Terenzio","family":"Cosio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mazzilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Campione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.131398"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_72_17"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04864.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371760"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb00206.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.168"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1998.tb00315.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0368com"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.10.003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160425"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00272.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07691-z"}],"container-title":["Skin Appendage Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:03:26Z","timestamp":1745424206000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000503758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,25]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,21]]},"published-print":{"date-parts":[[2020,1,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000503758","archive":["Portico"],"relation":{},"ISSN":["2296-9195","2296-9160"],"issn-type":[{"value":"2296-9195","type":"print"},{"value":"2296-9160","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,25]]}}}