{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:28:34Z","timestamp":1767997714922,"version":"3.49.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; To identify the clinical characteristics of polypoidal choroidal vasculopathy (PCV) in Caucasian patients and assess the prevalence of anti-vascular endothelial growth factor (anti-VEGF) resistance. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This involved a retrospective chart review of Caucasian patients diagnosed with PCV and utilizing indocyanine green angiography with the scanning laser ophthalmoscope. Data collected included patients\u2019 demographics, disease characteristics, and treatment response. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; There were 54 eyes of 49 patients with PCV; 51.0% were male and 49.0% were female with a mean age of 72.9 years. Forty-four patients (89.8%) had PCV unilaterally and 10.2% (5 patients) had PCV bilaterally. PCV was located in the macula in 79.6%, in the peripapillary region in 16.7%, and in both regions in 3.7%. PCV commonly presents with serous detachment (66.7%), retinal pigment epithelial detachment (RPED) (51.9%) and subretinal hemorrhage (37.0%). Twenty-nine eyes were included in the treatment response analysis, with 18 eyes (62.1%) showing persistent disease activity after 3 initial injections of anti-VEGF treatment. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; PCV in Caucasian patients is more often unilateral and presents more commonly in the macular region than the peripapillary region. Serous detachment and RPED are the 2 most common findings. Resistance to current anti-VEGF treatment was noted frequently; it is thus extremely important to identify this subtype of type I subretinal neovascularization.<\/jats:p>","DOI":"10.1159\/000503834","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T22:00:30Z","timestamp":1573250430000},"page":"178-186","source":"Crossref","is-referenced-by-count":13,"title":["Clinical Characteristics of Polypoidal Choroidal Vasculopathy and Anti-Vascular Endothelial Growth Factor Treatment Response in Caucasians"],"prefix":"10.1159","volume":"243","author":[{"given":"Gregg\u00a0T.","family":"Kokame","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelli\u00a0A.","family":"Kokame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle\u00a0N.","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jase\u00a0N.","family":"Omizo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13114"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.11.019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181e7976b"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101307010082"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001556"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.03.047"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s004170000180"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.11.1503"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000255"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182695bf8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000439359"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.04.018"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-310074"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2017.02.014"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303444"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.05.035"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.02.012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.4030"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.032466"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199010010-00001"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-017-0060-4"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.008"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0158-4"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.10.1392"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02329.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700706"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200104000-00004"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.01.003"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:04:24Z","timestamp":1745424264000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000503834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,8]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,5,7]]},"published-print":{"date-parts":[[2020,5,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000503834","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,8]]}}}