{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:50:54Z","timestamp":1759161054480,"version":"3.40.5"},"reference-count":27,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To evaluate resonance frequency (RF) values via dehydration effects in the inner ear caused by the glycerol test, which is used as a diagnostic method for M\u00e9ni\u00e8re\u2019s disease (MD). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Twenty adult patients with unilateral MD were included in the study. Before, and then at 1, 2, and 3 h after administration of glycerol (1 g\/kg), pure-tone hearing levels (125\u20138,000 kHz) and multifrequency tympanometry tests were performed. As a control, the RF values of the ears of 25 healthy subjects (i.e., 50 ears) were compared to the affected and unaffected ears in the 20 MD patients. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; There was a significant difference between the RF values of affected and healthy ears before glycerol administration (&lt;i&gt;p&lt;\/i&gt; = 0.047). The RF values before and after glycerol administration into affected ears were compared. The average RF values decreased significantly from 748.0 \u00b1 402.1 to 808.0 \u00b1 410.1 Hz at 1 h after glycerol intake, and this value increased during the subsequent hours. There were no statistically significant differences between the pure-tone levels before and 1 h after glycerol administration, but a significant decrease was observed at 3 h. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; We suggest that MD has different inner-ear dynamics and normal RF values when compared to healthy ears. Furthermore, decreased inner ear pressure causes reduction of the mass effect and a stiffening of the annular ligament. We conclude that pre- and post-RF tests should be added to the test battery for diagnosis of MD.<\/jats:p>","DOI":"10.1159\/000503845","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T22:01:17Z","timestamp":1573855277000},"page":"285-292","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Glycerol Test on Resonance Frequency in Patients with M\u00e9ni\u00e8re\u2019s Disease"],"prefix":"10.1159","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-4566","authenticated-orcid":false,"given":"Isilay","family":"Oz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evren","family":"Hizal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman\u00a0Halit","family":"Cam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent\u00a0Naci","family":"Ozluoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650902849123"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109\/00206097609071767"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00028-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4081\/audiores.2016.147"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000097795"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000604"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000178136.81729.7c"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199602000-00002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-011-0470-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2017.05.008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31825d9a72"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3109\/01050398409042134"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199312000-00006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2014.952045"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00020-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200209000-00021"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2005.4092"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5606\/kbbihtisas.2013.32391"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/01.aud.0000194516.18632.d2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199708000-00007"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000346343"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2188\/jea.10.1sup_26"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1177\/019459989010200618"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3109\/00206098909081618"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199806000-00007"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.8.815"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:04:28Z","timestamp":1745424268000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000503845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,1,29]]},"published-print":{"date-parts":[[2020,2,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000503845","archive":["Portico"],"relation":{},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"type":"print","value":"1420-3030"},{"type":"electronic","value":"1421-9700"}],"subject":[],"published":{"date-parts":[[2019]]}}}