{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:13:15Z","timestamp":1775664795089,"version":"3.50.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Interleukin-33 (IL-33) is reported to be involved in Th2-skewed eosinophilic inflammation. A recent study also found that IL-33 exerted opposite effects on Th17 response in different diseases. However, the role of IL-33 in chronic rhinosinusitis with nasal polyps (NPs) was not explored. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The purpose of this study was to investigate the expression and function of IL-33 in chronic rhinosinusitis with NPs. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; NP tissues from 60 NP patients and normal tissues of the inferior turbinate from 20 controls were sampled in operation. Immunochemistry was performed to identify eosinophilic or non-eosinophilic NPs. The expressions of IL-33 and Th1\/2\/17 cytokines were compared between different subtypes of NPs. The effect of IL-33 on Th response was detected in dispersed nasal polyp cells (DNPCs), and the signaling pathways involved in the process were detected using Western blot. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The concentration of IL-33 was signi\ufb01cantly elevated in both eosinophilic and non-eosinophilic NPs compared with controls. By in vitro study, we found that IL-33 can induce IL-4 and IL-5 production from eosinophilic DNPCs through the PI3K\/AKT pathway, whereas IL-33 can induce IL-17 production from non-eosinophilic DNPCs through the ERK1\/2 pathway. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; IL-33 is involved in Th2\/Th17 response in NPs. Our study suggests that different types of NPs need a different treatment target.<\/jats:p>","DOI":"10.1159\/000503976","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T22:00:33Z","timestamp":1574978433000},"page":"34-39","source":"Crossref","is-referenced-by-count":15,"title":["Interleukin-33 Promotes Th2\/Th17 Response in Eosinophilic and Non-Eosinophilic Nasal Polyps"],"prefix":"10.1159","volume":"82","author":[{"given":"Xianglin","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaxiong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujuan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.06.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2014.12.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.041"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin15.271"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/all.12064"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2010.02316.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200805-666OC"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.04.014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24462"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201212-2227OC"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000122"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.079"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.09.004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.13-RAI-0538"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4176"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-208772"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4260-6"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503976","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:06:20Z","timestamp":1745424380000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000503976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,28]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,21]]},"published-print":{"date-parts":[[2020,1,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000503976","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,28]]}}}