{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:11:59Z","timestamp":1785557519711,"version":"3.56.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction:<\/i><\/b> The renal bacterial colonization has not been explored so far. <b><i>Objective:<\/i><\/b> The aim of this study was to describe the renal microbiome and to determine differences of the renal microbiome in healthy and tumor-bearing parenchyma. <b><i>Methods:<\/i><\/b> Ten biopsies from patients undergoing laparoscopic nephrectomy for renal carcinoma with no history of urinary tract infections within the last 6 months were included in this study. The identification of all microorganisms was done using 16S DNA sequencing. The beta diversity analysis was performed by Bray-Curtis dissimilarity. <b><i>Results:<\/i><\/b> In all kidney samples, a plethora of microorganisms was found, with significant differences between benign and malignant renal tissue (<i>p<\/i> &#x3c; 0.0001). <b><i>Conclusions:<\/i><\/b> There is evidence that healthy kidney tissue as well as renal cell cancer tissue have a specific microbiome, thus opening new perspectives in renal physiology and tumor pathogenesis.<\/jats:p>","DOI":"10.1159\/000504029","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T17:01:17Z","timestamp":1573837277000},"page":"247-252","source":"Crossref","is-referenced-by-count":37,"title":["The Microbiome in Benign Renal Tissue and in Renal Cell Carcinoma"],"prefix":"10.1159","volume":"104","author":[{"given":"Stefan","family":"Heidler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5284-7276","authenticated-orcid":false,"given":"Lukas","family":"Lusuardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Madersbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Freibauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.361"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14028"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.04.040"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2174\/1874285801408010148"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-12-205"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.01.088"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-174"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014116"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.02.043"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.09.075"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00572-06"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.440"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12381"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu287"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-1275"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3892\/or.18.1.41"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh014"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.1.97"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.07.033"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00167"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000282409"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000475138"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000058450"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.50970"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4972"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:07:02Z","timestamp":1745410022000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":25,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2020,5,6]]},"published-print":{"date-parts":[[2020,5,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000504029","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.2.10964\/v1","asserted-by":"object"}]},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]}}}