{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:46:09Z","timestamp":1792194369207,"version":"4.4.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Aim:<\/i><\/b> <i>Helicobacter pylori<\/i> infection has been established as a definite risk factor for gastric cancer. However, the consequence of <i>H. pylori<\/i> eradication on the progression of gastroesophageal reflux disease (GERD) remains controversial. The purpose of our study was to investigate the relationship between <i>H. pylori<\/i> eradication and the development of GERD. <b><i>Methods:<\/i><\/b> A comprehensive, English literature search was performed from January 1990 to April 2019. Only randomized controlled trials (RCT) that evaluated the effect of <i>H. pylori<\/i> eradication on GERD were included. Meta-analysis of pooled OR was performed using Review Manger 5.1.7. <b><i>Results:<\/i><\/b> Seventeen articles with 6,889 subjects (intention-to-treat) that fulfilled the inclusion criteria were finally included in the analysis. Of them, 8 RCTs have the similar study design and inclusion criterion, which included patients with <i>H. pylori<\/i> infection but without GERD at baseline. The OR for the development of erosive GERD after <i>H. pylori<\/i> eradication was 1.67 (95% CI 1.12\u20132.48, <i>p<\/i> = 0.01). The OR for the development of GERD-related symptoms after <i>H. pylori<\/i> eradication in eradication group compared with control group was 1.04 (95% CI 0.84\u20131.29, <i>p<\/i> = 0.71). In addition, 9 RCTs included patients with both baseline <i>H. pylori<\/i> infection and GERD. The OR for the healing rates and relapse rates after <i>H. pylori<\/i> eradication in the <i>H. pylori<\/i> eradication group vs. control group was 0.92 (95% CI 0.47\u20131.82, <i>p<\/i> = 0.82) and 1.12 (95% CI 0.60\u20132.09, <i>p<\/i> = 0.71), respectively. <b><i>Conclusions:<\/i><\/b> Our meta-analyses showed <i>H. pylori<\/i> eradication may lead to the development of new erosive GERD. However, eradication of <i>H. pylori<\/i> may affect neither the healing rates nor relapse rates of preexisting GERD.<\/jats:p>","DOI":"10.1159\/000504086","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T21:00:25Z","timestamp":1589317225000},"page":"261-268","source":"Crossref","is-referenced-by-count":33,"title":["The Effect of <b><i>Helicobacter pylori<\/i><\/b> Eradication in Patients with Gastroesophageal Reflux Disease: A Meta-Analysis of Randomized Controlled Studies"],"prefix":"10.1159","volume":"38","author":[{"given":"Yan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuixiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,5,12]]},"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:07:25Z","timestamp":1745424445000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,7,3]]},"published-print":{"date-parts":[[2020,7,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000504086","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}