{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:41:21Z","timestamp":1771638081433,"version":"3.50.1"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Bronchoscopic lung volume reduction using the Zephyr\u00ae endobronchial valve (EBV) is a guideline treatment for patients with advanced emphysema. To achieve volume reduction, it is crucial that there is absence of collateral ventilation and a complete occlusion of the target lobe. While 3 EBV sizes (4.0; 4.0-LP; and 5.5) are currently available to accommodate all airway sizes, local anatomical variations sometimes warrant a valve with a wide diameter but shorter length. To address this, a new \u201clow profile\u201d 5.5-LP EBV has been introduced. <b><i>Objective:<\/i><\/b> In this study, we evaluated the feasibility, safety, and efficacy of this new 5.5-LP EBV. <b><i>Methods:<\/i><\/b> This was a single-center, prospective, open-label study. Patients were included if eligible for valve treatment with a local anatomy suitable to place at least one 5.5-LP EBV. Feasibility of placement of the 5.5-LP EBV was reported. Safety, CT parameters, pulmonary function tests, and St. George\u2019s Respiratory Questionnaire (SGRQ) were assessed at baseline and 6 weeks after treatment. <b><i>Results:<\/i><\/b> We included 30 patients with severe chronic obstructive pulmonary disease (forced expiratory volume in 1 s [FEV<sub>1<\/sub>] 29 \u00b1 10%; [RV] 242 \u00b1 46%; and SGRQ 56 \u00b1 11 points). Besides the regular EBV sizes, a median of 1 (1\u20133) of the new 5.5-LP EBV was placed. No valve adjustment was needed during the initial procedure. A single asymptomatic small pneumothorax was observed in 1 patient. In 4 patients, a revision bronchoscopy was performed due to absence of clinical benefit. In 1 patient, this was related to a dislocation of the 5.5-LP EBV. Clinically relevant improvements were seen in target lobar volume reduction (\u20131,554 mL), FEV<sub>1<\/sub> +39%, RV \u2013960 mL, and SGRQ \u201318 points. <b><i>Conclusions:<\/i><\/b> In this first in human study, the 5.5-LP EBV could be placed into wide segments with a shorter landing length without unexpected complications and with good efficacy outcomes.<\/jats:p>","DOI":"10.1159\/000504182","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T22:00:33Z","timestamp":1574978433000},"page":"50-55","source":"Crossref","is-referenced-by-count":14,"title":["First in Human Experience of the Performance of the New 5.5-LP Size Zephyr Endobronchial Valve"],"prefix":"10.1159","volume":"99","author":[{"given":"Karin","family":"Klooster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies","family":"van\u00a0Dijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.\u00a0David","family":"Koster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9555-3422","authenticated-orcid":false,"given":"Dirk-Jan","family":"Slebos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.06.009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507807"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccmconference.2017.C95"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201803-0590OC"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00015312"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201607-1383OC"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30431-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000453588"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13178"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00219111"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00535-2015"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:08:11Z","timestamp":1745424491000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,26]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,7]]},"published-print":{"date-parts":[[2020,1,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000504182","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,26]]}}}