{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:30:25Z","timestamp":1747193425488,"version":"3.40.5"},"reference-count":15,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Cancer survivors have a 14% increased risk of developing a malignancy compared with the general population. Second radiation-induced malignancies with different histologies have been described in different organs. Based on individual observations, we hypothesized that neuroendocrine carcinoma (NEC) could arise in irradiated organs. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In a retrospective analysis of Gustave Roussy database of NEC patients (small cell lung cancer excluded) diagnosed as a second cancer, we looked for the frequency of grade 3 NEC that arose in patients who had received previous radiation therapy for a first cancer. Radiation therapy for the first cancer, dose, location of radiation therapy, pathological characteristics, overall survival, and response to treatment of secondary NEC were analyzed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; From January 1995 to December 2017, 847 cases of NEC were seen at Gustave Roussy. Among them, 95 (11.2%) patients had a history of previous malignancy of which 36 (4%) had been treated with radiation therapy. Out of these 36 patients, 12 (1.4% of all NEC patients) developed a NEC within the previous irradiated organ (median dose of 50 Gy, range 36\u201367.5). Most frequent first cancers were breast cancer (&lt;i&gt;n&lt;\/i&gt; = 4) and Hodgkin lymphoma (&lt;i&gt;n&lt;\/i&gt; = 3). NEC arose within a median time of 21.7 years (range 5.1\u201336.4) from radiation in the thorax (&lt;i&gt;n&lt;\/i&gt; = 5), digestive tract (&lt;i&gt;n&lt;\/i&gt; = 3), and other sites. Five large cell NEC, 3 small cell NEC, 1 mixed neuroendocrine neoplasm and 3 not otherwise specified NEC were diagnosed. Ten patients had stage IV disease at diagnosis; median overall survival was 37.8 months (95% CI [17.6 to NA]). Three patients (25%) achieved complete response with multimodal treatment. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; NEC can arise from previously irradiated organs and may have a better outcome in this setting. Other risk factors should be investigated to explain the high rate of previous cancer in this population of neuroendocrine neoplasm. <\/jats:p>","DOI":"10.1159\/000504255","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T21:00:36Z","timestamp":1571864436000},"page":"139-145","source":"Crossref","is-referenced-by-count":2,"title":["Post-Radiation Grade 3 Neuroendocrine Carcinoma: A New Entity?"],"prefix":"10.1159","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1276-3289","authenticated-orcid":false,"given":"Julien","family":"Hadoux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Yves","family":"Scoazec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Burtin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Planchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Malka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandine","family":"Berdelou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Boige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Duvillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Leboulleux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Faron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lambros","family":"Tselikas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Deutsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Ducreux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Baudin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph9124744"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70061-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605435"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.2.312"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.551"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22197"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1971)28:5<1087::AID-CNCR2820280502>3.0.CO;2-F"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194805)1:1<3::AID-CNCR2820010103>3.0.CO;2-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22791"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181671491"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0110-y"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.847"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds276"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.04.009"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690325"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:08:47Z","timestamp":1745424527000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,22]]},"references-count":15,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2020,12,10]]},"published-print":{"date-parts":[[2020,12,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000504255","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"type":"print","value":"0028-3835"},{"type":"electronic","value":"1423-0194"}],"subject":[],"published":{"date-parts":[[2019,10,22]]}}}