{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:45:44Z","timestamp":1790721944025,"version":"4.1.0"},"reference-count":32,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Diabetes mellitus type 1 (DM1) is associated with a high risk for cardiovascular disease, and early detection of myocardial dysfunction is crucial for the prevention of cardiac complications. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to evaluate left ventricular (LV) and right ventricular (RV) function by using both conventional echocardiography as well as multi-layered speckle tracking echocardiography (STE) in young adults with DM1. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We included 50 young asymptomatic adults diagnosed with DM1 (mean interval from diagnosis 9 \u00b1 6 years) and 80 healthy controls. STE was acquired using the GE Vivid S60 equipment. The LV longitudinal strain (LS), layer-specific strains of the endocardium, myocardium, and epicardium (global longitudinal strain [GLS]&lt;sub&gt;endo&lt;\/sub&gt;, GLS&lt;sub&gt;myo&lt;\/sub&gt;, GLS&lt;sub&gt;epi&lt;\/sub&gt;) as well as RV strain were obtained using the EchoPAC BT13 workstation. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; No significant intergroup differences in LV ejection fraction were noted. GLS&lt;sub&gt;endo&lt;\/sub&gt; and GLS&lt;sub&gt;myo&lt;\/sub&gt; were reduced in the DM1 group (\u201320.6 \u00b1 2.7 vs. \u201322.0 \u00b1 2.3 and \u201318.0 \u00b1 2.4 vs. \u201319.1 \u00b1 1.9, respectively, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05) compared to controls. Mechanical dispersion was higher in the diabetes group (34 \u00b1 11 vs. 29 \u00b1 7, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). RV strain measurements showed no significant difference between the groups. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Young adults with DM1 and without known heart disease have subclinical myocardial dysfunction with lower LV endocardium and myocardium LS and higher mechanical dispersion demonstrated by multi-layered STE.<\/jats:p>","DOI":"10.1159\/000504532","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T22:00:33Z","timestamp":1576101633000},"page":"80-87","source":"Crossref","is-referenced-by-count":9,"title":["Myocardial Function Assessed by Multi-Layered Two-Dimensional Speckle Tracking Analysis in Asymptomatic Young Subjects with Diabetes Mellitus Type 1"],"prefix":"10.1159","volume":"145","author":[{"given":"Mihaela","family":"Berceanu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Mirea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionut","family":"Donoiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Militaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"S\u0103ftoiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavian","family":"Istr\u0103toaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.03.024"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.10.1134"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i13.1246"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052187"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1116-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/2040622315598502"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0728-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(72)90595-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-012-9313-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2012.06.007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00365.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(74)90089-7"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.9.1614"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.22.2668"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60471-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.173997"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep097"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1253\/circj.72.189"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.110.959817"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.12.001"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9131-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2018.06.019"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.04.025"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.10.004"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2016.02.006"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.12.020"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.11.012"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.01.010"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.20.2495"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04383-4"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:11:39Z","timestamp":1745424699000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,11]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,4]]},"published-print":{"date-parts":[[2020,2,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000504532","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,11]]}}}