{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:58:04Z","timestamp":1783490284758,"version":"3.55.0"},"reference-count":38,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We compared the effects of the chloride-regaining diuretic acetazolamide with those of conventional diuretics on plasma volume, serum electrolytes, and renal function in acutely decompensated heart failure (HF) patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A retrospective analysis was performed on the data of 13 patients treated with acetazolamide (Group A) and 13 patients with conventional diuretics (Group B) matched based on diuresis-induced weight reduction (\u22651 kg) during resolution of worsening HF. Changes in plasma volume (Strauss formula), renal function, and serum electrolytes under treatment were determined by peripheral blood tests. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Clinical characteristics at baseline were not different between groups A and B. After diuretic therapy, body weight reduction (\u20132.23 \u00b1 1.11 vs. \u20132.22 \u00b1 1.06 kg, &lt;i&gt;p&lt;\/i&gt; = 0.97) and the number of residual HF-related signs (0.31 \u00b1 0.48 vs. 0.23 \u00b1 0.44, &lt;i&gt;p&lt;\/i&gt; = 0.67) was not different between groups. After each treatment, the serum chloride concen\u00adtration increased in Group A, but decreased in Group B (+5.31 \u00b1 4.91 vs. \u2013 4.54 \u00b1 4.68 mEq\/L, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001). Plasma volume (0.63 \u00b1 13.1 vs. \u201312.1 \u00b1 10.5%, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01) and renal function determined by changes in serum creatinine concentration (0.048 \u00b1 0.12 vs. 0.21 \u00b1 0.24 mg\/dL, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.047) were preserved in Group A compared with Group B. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; While both groups exhibited equivalent body weight reduction and resolution of HF-related signs after each diuretic treatment, acetazolamide treatment preserved plasma volume and renal function compared to conventional diuretics.<\/jats:p>","DOI":"10.1159\/000504533","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T22:00:33Z","timestamp":1576792833000},"page":"215-223","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Changes in Plasma Volume and Renal Function between Acetazolamide and Conventional Diuretics: Understanding the Mechanical Differences according to the \u201cChloride Theory\u201d"],"prefix":"10.1159","volume":"145","author":[{"given":"Hajime","family":"Kataoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003180"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.09.014"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.12.059"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2018.09.014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12191"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2017.06.005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195305212482102"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195405062501803"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195405132501902"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-42-2-358"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/AC.70.3.3080630"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-017-0577-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2017.10.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12465"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12043"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00602-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000895"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-0938"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.215"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.034"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-011-0713-z"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2016.08.005"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.5.1.58"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12016"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102530"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.770834"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.01.054"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.94"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1229"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2018.1455947"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00195.2005"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-1122"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/yty076"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.095"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.013"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.140"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1307"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:11:40Z","timestamp":1745424700000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,19]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,20]]},"published-print":{"date-parts":[[2020,5,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000504533","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,19]]}}}