{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:52:54Z","timestamp":1774029174731,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiorenal Med"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction:<\/i><\/b> The ratio of contrast media volume to glomerular filtration rate (contrast\/GFR) has been shown to correlate with the occurrence of contrast-induced acute kidney injury (CI-AKI) in unselected patient populations who underwent percutaneous coronary intervention (PCI). <b><i>Objective:<\/i><\/b> We evaluated the possible utilization of this marker and optimal cutoff among ST-elevation myocardial infarction (STEMI) patients undergoing primary PCI. <b><i>Methods:<\/i><\/b> We retrospectively included 419 patients with STEMI treated with primary PCI. The occurrence of CI-AKI was defined by the KDIGO criteria as an increase in serum creatinine of \u22650.3 mg\/dL within 48 h following PCI. A receiver-operator characteristic (ROC) curve was used to identify the optimal cutoff value of contrast\/GFR ratio to predict CI-AKI. This value was then assessed using multivariable logistic regression. <b><i>Results:<\/i><\/b> The overall incidence of CI-AKI was 9%. The contrast\/GFR ratio was significantly higher among patients with CI-AKI (2.7 \u00b1 1.2 vs. 1.9 \u00b1 0.9; <i>p<\/i> &#x3c; 0.001). According to the ROC curve analysis, the optimal cutoff value of contrast\/GFR ratio to predict AKI was measured as \u22652.13, with 70% sensitivity and 60% specificity (AUC 0.65, 95% CI 0.56\u20130.74; <i>p<\/i> = 0.002). In a multivariate logistic regression model, contrast\/GFR ratio \u22652.13 was independently associated with CI-AKI (OR 2.46, 95% CI 1.09\u20135.57; <i>p<\/i> = 0.03). <b><i>Conclusions:<\/i><\/b> Among STEMI patients undergoing primary PCI, contrast\/GFR ratio \u22652.13 was independently associated with CI-AKI.<\/jats:p>","DOI":"10.1159\/000504534","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T22:02:10Z","timestamp":1575496930000},"page":"108-115","source":"Crossref","is-referenced-by-count":7,"title":["Contrast Volume to Glomerular Filtration Ratio and Acute Kidney Injury among ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention"],"prefix":"10.1159","volume":"10","author":[{"given":"David","family":"Zahler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keren-Lee","family":"Rozenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Merdler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogev","family":"Peri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yacov","family":"Shacham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-014-0680-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181b9eb3b"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.970160"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.05.023"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr494"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/02841850500335051"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.03.058"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu063"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.11.046"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.03.146"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2012.04.011"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/cc11454"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12061"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)01070-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-3-200902030-00006"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.09.022"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-017-0461-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.08.056"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000590"}],"container-title":["Cardiorenal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504534","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:11:42Z","timestamp":1745424702000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,4]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,3,3]]},"published-print":{"date-parts":[[2020,3,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000504534","archive":["Portico"],"relation":{},"ISSN":["1664-3828","1664-5502"],"issn-type":[{"value":"1664-3828","type":"print"},{"value":"1664-5502","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,4]]}}}