{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:03:24Z","timestamp":1787997804114,"version":"build-2784847793"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction:<\/i><\/b> Common variable immunodeficiency (CVID) is characterized by recurrent infections, autoimmunity, lymphoproliferation, hypogammaglobulinemia, and defective antibody production. In CVID, B-cell abnormalities were described to predict end organ involvement and prognosis. Pediatric-onset CVID is much rarer than adult CVID, and lymphocyte subset abnormalities have not been thoroughly evaluated. <b><i>Objective:<\/i><\/b> We sought to determine lymphocyte subset abnormalities and their association with end organ involvement in pediatric-onset CVID patients. <b><i>Methods:<\/i><\/b> The clinical manifestations and laboratory findings including absolute numbers and percentages of B-, T-, and NK cell populations were assessed in pediatric-onset CVID patients and compared to age-matched healthy controls. The patients were divided into 2 groups according to age at assessment (pediatric CVID patients: 10\u201316 years, <i>n<\/i> = 9; and adult CVID patients: &#x3e;16 years, <i>n<\/i> = 13). The comparisons between lymphocyte subsets and organ involvement were also evaluated. <b><i>Results:<\/i><\/b> Mean age at symptom onset was 18 (3\u2013204) months. All CVID patients with pediatric onset had decreased levels of total and memory B cells, CD4<sup>+<\/sup> T cells, CD4<sup>+<\/sup>CD45RA<sup>+<\/sup> naive T cells, and recent thymic emigrant (RTE) cells. On the other hand, they had increases in CD8<sup>+<\/sup>CD45RO<sup>+<\/sup> memory T cells. Interestingly, adult CVID patients demonstrated high frequencies of activated and double-negative T cells, which were unique only for this group of patients. Specific cellular abnormalities associated with the reduction in B and NK cells and increase in CD8<sup>+<\/sup> T cells were found in patients with bronchiectasis. Moreover, in pediatric CVID patients, low serum IgA levels and decreased numbers of naive T and RTE cells were determined as risk factors for chronic diarrhea. <b><i>Conclusions:<\/i><\/b> Specific abnormalities in B- and T-lymphocyte compartments were identified in pediatric-onset CVID patients and appear to be associated with end organ manifestations.<\/jats:p>","DOI":"10.1159\/000504598","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T22:00:34Z","timestamp":1578088834000},"page":"228-237","source":"Crossref","is-referenced-by-count":21,"title":["Lymphocyte Subset Abnormalities in Pediatric-Onset Common Variable Immunodeficiency"],"prefix":"10.1159","volume":"181","author":[{"given":"Ismail","family":"Ogulur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayca","family":"Kiykim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Baser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Karakoc-Aydiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa","family":"Baris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.049"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70268-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-017-0465-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3638-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32835914b9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1544"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025373601374"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-091744"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1586\/eci.13.30"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.07.025"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-018-0575-y"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.07.003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.6.3932"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-010-9424-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2010.10.002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.11.010"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01004.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02609.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.07.006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-321695"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.2.674.bloodjournal872674"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.11.003"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01187.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.10.048"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01317.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:12:40Z","timestamp":1745424760000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,2,26]]},"published-print":{"date-parts":[[2020,2,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000504598","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}