{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:47:36Z","timestamp":1758278856650,"version":"3.40.5"},"reference-count":10,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Few studies have reported the measurement of anatomical dead space (V<sub>d,an<\/sub>) and alveolar tidal volume (V<sub>A<\/sub>) in ventilated neonates with respiratory distress. <b><i>Objective:<\/i><\/b> The aim of this study was to determine the differences in V<sub>d,an<\/sub> and V<sub>A<\/sub> in ventilated infants between the early and recovery phases of respiratory distress using volumetric \u00adcapnography (V<sub>cap<\/sub>) based on ventilator graphics and capnograms. <b><i>Methods:<\/i><\/b> This study enrolled twenty-five ventilated infants (mean birth weight, 2,220 \u00b1 635 g; mean gestational age, 34.7 \u00b1 3.3 weeks). We adjusted respiratory settings to maintain appropriate oxygenation and tidal volume (V<sub>T<\/sub>), and performed V<sub>cap<\/sub> based on waveforms of ventilator graphics and capnograms. V<sub>d,an<\/sub> and V<sub>A<\/sub>were measured in infants with respiratory disorders, immediately after intubation (early phase) and subsequently when they were clinically stable (recovery phase). <b><i>Results:<\/i><\/b> The early phase, with lower dynamic lung compliance, required a higher level of ventilator support, not positive end-expiratory pressure, than the recovery phase. There were significant differences between the early and recovery phases for V<sub>d,an<\/sub> (mean difference in V<sub>d,an<\/sub>\/kg = 0.57 mL\/kg; 95% confidence interval [CI], 0.38\u20130.77; mean difference in V<sub>d,an<\/sub>\/V<sub>T<\/sub> = 0.10; 95% CI, 0.07\u20130.14) and V<sub>A<\/sub> (mean difference in V<sub>A<\/sub>\/kg = \u20130.60 mL\/kg; 95% CI, \u20130.94 to \u20130.27; mean difference in V<sub>A<\/sub>\/V<sub>T<\/sub> = \u20130.12; 95% CI, \u20130.15 to \u20130.09), despite no difference in V<sub>T<\/sub>. <b><i>Conclusions:<\/i><\/b> We evaluated changes in V<sub>d,an<\/sub> and V<sub>A<\/sub> during mechanical ventilation using V<sub>cap<\/sub> based on waveforms. The increase in V<sub>d,an<\/sub> and decrease in V<sub>A<\/sub> suggested dilation of the airways and collapse of the alveoli in ventilated infants with low lung compliance.<\/jats:p>","DOI":"10.1159\/000504710","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T22:00:33Z","timestamp":1576101633000},"page":"189-192","source":"Crossref","is-referenced-by-count":3,"title":["Ventilated Infants Have Increased Dead Space and Lower Alveolar Tidal Volumes during the Early versus Recovery Phase of Respiratory Distress"],"prefix":"10.1159","volume":"117","author":[{"given":"Masashi","family":"Zuiki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Yamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Goda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Oya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2084-7183","authenticated-orcid":false,"given":"Hiroshi","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016\/j.jcrc.2018.01.005"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016\/j.jpeds.2013.09.034"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1007\/s001340050933"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1186\/s12938-016-0228-4"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1159\/000366153"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1152\/ajplegacy.1948.154.3.405"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1152\/ajplung.00288.2013"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1002\/ppul.21616"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1159\/000143721"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1186\/s13054-016-1377-3"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:14:04Z","timestamp":1745424844000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,11]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,7,23]]},"published-print":{"date-parts":[[2020,7,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000504710","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.11353772","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2019,12,11]]}}}