{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:26:54Z","timestamp":1745468814559,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Purpose:<\/i><\/b> This study evaluates and characterizes the choroid underlying congenital hypertrophy of the retinal pigment epithelium (CHRPE). <b><i>Methods:<\/i><\/b> Retrospective observational study of CHRPE at least 2 mm in diameter. Choroidal vascular architecture was qualitatively examined. Choroidal thickness was measured by 2 independent observers using enhanced depth imaging spectral domain optical coherence tomography. <b><i>Results:<\/i><\/b> Forty-six eyes of 46 patients with CHRPE were included. Thirty-two lesions had imaging sufficient for analysis. Haller\u2019s layer was healthy in 18 (56%), thin in 13 (41%), and absent in 1 (2%). Sattler\u2019s layer was atrophic in 30 (94%), and choriocapillaris was atrophic in 31 (97%). CHRPE with thinned Haller\u2019s layer had significantly larger diameter. The mean sub-CHRPE choroidal thickness was 82.4 \u00b1 7.9 \u00b5m, compared to a thickness of 148.4 \u00b1 9.6 \u00b5m in the normal adjacent choroid (<i>p<\/i> &#x3c; 0.0001). Mean retinal thickness overlying the CHRPE was 77.3 \u00b1 4.3 \u00b5m, compared to a retinal thickness of 137.8 \u00b1 2.9 \u00b5m overlying the normal adjacent choroid (<i>p<\/i> &#x3c; 0.0001). Sub-CHRPE choroidal thickness was a mean of 56.2 \u00b1 3.1% of the adjacent normal choroidal thickness. <b><i>Conclusion:<\/i><\/b> The underlying choroid CHRPE is thinner than the adjacent normal choroid. All layers of the choroid can be thin with a preference of the inner Sattler\u2019s and choriocapillaris layers.<\/jats:p>","DOI":"10.1159\/000504712","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T22:00:33Z","timestamp":1582840833000},"page":"238-243","source":"Crossref","is-referenced-by-count":1,"title":["Optical Coherence Tomography Characteristics of the Choroid Underlying Congenital Hypertrophy of the Retinal Pigment Epithelium"],"prefix":"10.1159","volume":"6","author":[{"given":"Jasmine\u00a0H.","family":"Francis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan\u00a0K.","family":"Sobol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Folberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David\u00a0H.","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(75)90069-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-198909010-00006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32464-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.061887"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00618-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20101031-04"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31821f2d8b"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000420"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.057"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/01.ICB.0000264810.79235.29"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20130503-19"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.016"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.154384"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3205\/oc000078"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310406"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1975.01010020861007"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504712","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:14:05Z","timestamp":1745424845000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,8,19]]},"published-print":{"date-parts":[[2020,8,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000504712","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"type":"print","value":"2296-4681"},{"type":"electronic","value":"2296-4657"}],"subject":[],"published":{"date-parts":[[2020]]}}}