{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:27:22Z","timestamp":1768091242131,"version":"3.49.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objectives:<\/i><\/b> This in situ study aimed to evaluate whether rinsing with a calcium-containing solution prior to an erosive attack reduces the softening of enamel. <b><i>Materials and Methods:<\/i><\/b> A total of 240 bovine enamel samples with determined baseline surface microhardness (KHN) were allocated to 5 runs in which each of the 12 volunteers performed the following experiment: 4 enamel samples were inserted in a custom-made intraoral appliance and carried in the mouth (upper jaw) for 30 min before each volunteer either rinsed his mouth for 60 s with a fluoride- and stannous ion-containing dental erosion protection mouth rinse as positive control (run 1), milk (run 2), a solution prepared from a 500-mg calcium effervescent tablet dissolved in 100 mL (run 3) or 200 mL (run 4) water, or did not perform any rinsing with a test solution before the erosive attack (run 5, negative control). To simulate the erosive attack, volunteers rinsed their mouth with a commercial soft drink (Sprite Zero) for 60 s and afterwards with water to stop the erosive process. Finally, surface microhardness was measured again and hardness loss (\u0394KHN) calculated. A mixed effect model was fitted to the data set to investigate whether the different runs showed differences with respect to \u0394KHN. <b><i>Results:<\/i><\/b> No significant difference in softening of enamel (mean of \u0394KHN; lower confidence level\/upper confidence level) was observed between the negative control run 5 (50.7; 60.8\/40.6), run 2 (50.7; 60.8\/40.6), run 3 (38.7; 48.8\/28.6) and run 4 (40.7; 50.8\/30.6) (<i>p<\/i> &#x3e; 0.05, respectively). Enamel softening in the positive control run 1 (25.4; 35.6\/15.3) was significantly lower compared to the softening in run 5 (<i>p<\/i> &#x3c; 0.001). No significant difference was observed between run 1 and run 3 (<i>p<\/i> = 0.09). <b><i>Conclusion:<\/i><\/b> Other than the fluoride- and stannous ion-containing dental erosion protection mouth rinse, none of the investigated calcium-containing solutions is able to significantly reduce erosion-induced softening of enamel.<\/jats:p>","DOI":"10.1159\/000504747","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T22:00:37Z","timestamp":1578434437000},"page":"127-133","source":"Crossref","is-referenced-by-count":5,"title":["Prevention of Enamel Softening by Rinsing with a Calcium Solution before Dental Erosion"],"prefix":"10.1159","volume":"54","author":[{"given":"Philipp","family":"K\u00f6rner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel\u00a0B.","family":"Wiedemeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Attin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian\u00a0Just","family":"Wegehaupt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.10.014"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(03)00156-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2007.07.007"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000360355"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2004.01056.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2842.2001.00780.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.1996.tb00855.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1590\/1678-775720150127"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000402436"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510375291"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.11.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000360376"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000359942"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1951.sp004584"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690S114"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2341\/09-BL"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000074360"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511002820"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2013.12.009"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000262343"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.12.007"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000445758"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2015.10.019"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2018.01.002"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2016.07.003"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01797.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2014.07.009"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2010.06.006"}],"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:14:18Z","timestamp":1745424858000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,8,19]]},"published-print":{"date-parts":[[2020,8,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000504747","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"value":"0008-6568","type":"print"},{"value":"1421-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}