{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:30:43Z","timestamp":1747193443695,"version":"3.40.5"},"reference-count":18,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; In the last century, there have been major changes within the population structure in Germany. The aim of this study was to determine the impact of a changing population structure on identification of familial prostate cancer (PCa), and to investigate how many and which types of other cancers have occurred in patients and their first-degree relatives. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 19,540 patients were evaluated in a prospectively collected PCa family database and divided into four birth cohorts: 1925\u20131934 (cohort A), 1935\u20131944 (cohort B), 1945\u20131954 (cohort C), and 1955\u20131964 (cohort D). Other primary cancers and cancers of first-degree relatives were evaluated. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The percentage of PCa patients with \u22652 sons declined (A: 28.9% to D: 21.6%). The percentage of patients whose fathers lived for \u226565 years increased (B: 64.2% to D: 73.0%). Malignancies of the skin, the urinary tract, and the lymphoid\/hematopoietic tissue were more common in patients with a positive first-degree PCa family history and their first-degree relatives. Additionally, first-degree relatives reported more often neoplasms of respiratory\/intrathoracic organs and the female breast. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; A small family size, an early deceased father, and a high number of sporadic cases complicate the identification of familial PCa patients. Thus, a detailed family history should also include unaffected first-degree relatives to avoid any misclassification. Findings of other primary cancers in patients and their relatives warrant further investigation.<\/jats:p>","DOI":"10.1159\/000504789","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T22:00:33Z","timestamp":1576879233000},"page":"222-229","source":"Crossref","is-referenced-by-count":3,"title":["Impact of a Changing Population Structure and Clustering of Cancer in Prostate Cancer Patients Depending on a First-Degree Family History"],"prefix":"10.1159","volume":"104","author":[{"given":"Valentin\u00a0Henri","family":"Meissner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Bittner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Kron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schiele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helga","family":"Schulwitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen\u00a0Erich","family":"Gschwend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0339-3394","authenticated-orcid":false,"given":"Kathleen","family":"Herkommer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000500350"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990170409"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S16747"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.0096"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11262"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2013.266"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3094"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000314281"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/sp\/jxr016"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00120-014-3617-y"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29075"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000056706.88960.7c"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28769"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-017-2122-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm414"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.02.002"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.10.044"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01598-9"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504789","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:14:36Z","timestamp":1745424876000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,20]]},"references-count":18,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2020,5,6]]},"published-print":{"date-parts":[[2020,5,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000504789","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2019,12,20]]}}}