{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:37:42Z","timestamp":1769603862901,"version":"3.49.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Neurol"],"abstract":"<jats:p>We present a case of primary orthostatic tremor (OT) responsive to dopaminergic medication. The patient was a 62-year-old woman, who had leg tremor on standing for 2 years. No parkinsonian or other neurological signs were observed. Surface electromyography of the quadriceps muscles showed regular 5\u20136 Hz muscle discharges. [&lt;sup&gt;123&lt;\/sup&gt;I]-FP-CIT DAT-SPECT imaging revealed decreased specific binding ratio values in the striatum compared with age-matched controls. Her leg tremor almost completely disappeared following administration of levodopa 200 mg and pramipexole 0.75 mg. Since her OT with low-frequency discharge was responsive to dopaminergic medication, we speculate that it may be a premotor sign of Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1159\/000504798","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T22:00:35Z","timestamp":1578088835000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Levodopa-Responsive Primary Slow Orthostatic Tremor: A Premotor Sign of Parkinson\u2019s Disease?"],"prefix":"10.1159","volume":"12","author":[{"given":"Fumihito","family":"Yoshii","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wakoh","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Aono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20132"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww268"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.01.042"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-3976-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27121"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.5.681"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.10.1519"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10475"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-018-0524-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22224"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21621"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.11019"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-018-3605-x"}],"container-title":["Case Reports in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504798","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:14:39Z","timestamp":1745424879000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,3]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,6,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000504798","archive":["Portico"],"relation":{},"ISSN":["1662-680X"],"issn-type":[{"value":"1662-680X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,3]]}}}