{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:40:10Z","timestamp":1770327610788,"version":"3.49.0"},"reference-count":7,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>We describe the first presentation of a deep penetrating nevus (DPN) on the lacrimal caruncle. This lesion was seen in an 18-year-old woman presenting with hemorrhage of a long-standing pigmented mass on the caruncle. Histology showed a combined melanocytic neoplasm that consisted of two different melanocytic components. The differential diagnosis, based on histological examination, was a conventional melanocytic nevus, a Spitz nevus, or a combined melanocytic nevus. On the molecular level, one of the components revealed a mutation in the &lt;i&gt;CTNNB1&lt;\/i&gt; gene encoding the \u03b2-catenin protein, while both components harbored a BRAF V600E mutation, without molecular features of a malignant melanocytic lesion. This presentation of a DPN of the lacrimal caruncle emphasizes the similarities of the caruncle with the skin.<\/jats:p>","DOI":"10.1159\/000504966","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T22:31:26Z","timestamp":1580250686000},"page":"293-296","source":"Crossref","is-referenced-by-count":8,"title":["Histopathological and Molecular Features of a Conjunctival Caruncular Deep Penetrating Nevus"],"prefix":"10.1159","volume":"6","author":[{"given":"Jolique\u00a0A.","family":"van\u00a0Ipenburg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Damman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dion","family":"Paridaens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-214X","authenticated-orcid":false,"given":"Robert\u00a0M.","family":"Verdijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.316"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2017.01.016"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-019-02533-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.77"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00758-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5522"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14901"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/504966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:16:34Z","timestamp":1745424994000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000504966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,8,19]]},"published-print":{"date-parts":[[2020,8,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000504966","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"value":"2296-4681","type":"print"},{"value":"2296-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}