{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:09:56Z","timestamp":1774494596648,"version":"3.50.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objectives:<\/i><\/b> Firstly, to describe the outcome of a series of fetuses with Ebstein\u2019s anomaly (EA) and, secondly, to study the utility of different second-trimester echocardiographic parameters to predict fetal and neonatal mortality. <b><i>Methods:<\/i><\/b> 39 fetuses with EA diagnosed between 18 and 28 weeks of gestation were included. Fetal echocardiography included the cardiothoracic ratio (CTR); right atrial (RA) area index; displacement of the tricuspid valve (TV); tricuspid regurgitation; pulmonary artery; and ductus arteriosus flow characteristics. Additionally, 2 novel parameters were obtained: the relative RA area ratio (RA area\/cardiac area) and the TV displacement index (TVDI, TV displacement distance\/longi\u00adtudinal diameter of the left ventricle). Correlation between the echocardiographic variables and the primary outcome of perinatal mortality or survival at 1 year of life was evaluated. <b><i>Results:<\/i><\/b> From the initial cohort, 8 cases were excluded due to complex congenital heart defects. Termination of pregnancy (TOP) was performed in 15 cases, and fetal death was diagnosed in 3 cases. In the live-born cohort of 13 patients, 4 died in the neonatal period, yielding a perinatal survival rate of 29 and 56%, respectively, after excluding TOP cases. Compared with survivors, nonsurvivors showed a significantly higher CTR (56.7 \u00b1 16.2 vs. 42.6 \u00b1 8.6; <i>p<\/i> = 0.04), relative RA area ratio (0.39 \u00b1 0.13 vs. 0.25 \u00b1 0.05; <i>p<\/i> = 0.01), and TVDI (0.62 \u00b1 0.17 vs. 0.44 \u00b1 0.12; <i>p<\/i> = 0.03) at diagnosis. The best model to predict perinatal mortality was obtained by using a scoring system which included the relative RA area ratio and TVDI (AUC 0.905 [95% CI 0.732\u20131.000]). <b><i>Conclusions:<\/i><\/b> Fetuses with a relative RA area ratio \u22650.29 and TVDI \u22650.65 at the second trimester have the highest risk of dying in the perinatal stage.<\/jats:p>","DOI":"10.1159\/000504979","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T22:00:31Z","timestamp":1580853631000},"page":"604-614","source":"Crossref","is-referenced-by-count":12,"title":["Prediction of Perinatal Mortality in Ebstein\u2019s Anomaly Diagnosed in the Second Trimester of Pregnancy"],"prefix":"10.1159","volume":"47","author":[{"given":"Narc\u00eds","family":"Masoller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"G\u00f3mez\u00a0del\u00a0Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6807-4944","authenticated-orcid":false,"given":"Ignacio","family":"Herraiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enery","family":"G\u00f3mez-Montes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Soveral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"P\u00e9rez-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3n","family":"Mart\u00ednez-Biosques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel\u00a0Angel","family":"Granados","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Bennasar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u00a0Clara","family":"Escobar-Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep\u00a0Mar\u00eda","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Galindo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.05.003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.015839"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.09.022"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90722-L"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90877-C"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)01009-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.04.024"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.11.049"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0355-z"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.03.008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2016.08.004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90291-T"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2939"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20302"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-003-0588-y"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10030174.x"}],"container-title":["Fetal 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