{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:40:15Z","timestamp":1779324015415,"version":"3.51.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> This study was designed to investigate the vitamin D (vit-D) and vitamin B12 (vit-B12) levels and their correlation with anti-thyroid peroxidase (anti-TPO) antibodies in patients with autoimmune hypothyroidism. <b><i>Methods:<\/i><\/b> A total of 130 patients diagnosed with autoimmune hypothyroidism were included in the study retrospectively. The patients were divided into two groups as those having vit-B12 levels below 200 pg\/mL (<i>n<\/i> = 60) and vit-B12 levels equal to or above 200 pg\/mL (<i>n<\/i> = 70). These two groups were compared in terms of age, sex, thyroid-stimulating hormone (TSH), free-T4 (FT4), vit-D, and anti-TPO. The correlation between vit-B12 and anti-TPO levels was also investigated in these groups. Patients were then divided into four groups according to their vit-D levels. Patients with normal vit-D levels (25[OH]D &#x3e;30 ng\/mL; <i>n<\/i> = 5), those with vit-D insufficiency (20\u201330 mg\/mL; <i>n<\/i> = 9), those with vit-D deficiency (10\u201320 ng\/mL; <i>n<\/i> = 43), and those with severe vit-D deficiency (&#x3c;10 ng\/mL; <i>n<\/i> = 73). These four groups were compared in terms of age, gender, TSH, FT4, vit-B12, and anti-TPO levels. In addition, the correlation between levels of vit-D and anti-TPO was also investigated. <b><i>Results:<\/i><\/b> We found that vit-B12 deficiency and vit-D deficiency were associated with autoimmune hypothyroidism, and that there was a negative correlation between vit-B12 and vit-D levels and anti-TPO antibodies in these patients. <b><i>Conclusion:<\/i><\/b> In patients with autoimmune hypothyroidism, vit-D and vit-B12 deficiency should be investigated at the time of diagnosis and periodically on follow-ups.<\/jats:p>","DOI":"10.1159\/000505094","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T22:00:25Z","timestamp":1575324025000},"page":"364-370","source":"Crossref","is-referenced-by-count":49,"title":["Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies"],"prefix":"10.1159","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0784-7146","authenticated-orcid":false,"given":"Hanife\u00a0\u015eerife","family":"Akta\u015f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.285606"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2016.31.2.213"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1967\/s002449910507"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1454"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2014.265"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4158\/EP12376"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2298\/MPNS1104183T"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31815c3b5b"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/ 2013\/509764"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-014-0418-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3945\/an.111.001370"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.179997"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.73"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-014-0064-y"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2014.55.2.476"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872016000500009"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055\/a-0856-1044"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.231\/JIM.0b013e31821b8755"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.10"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.6133\/apjcn"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200609000-00004"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:17:11Z","timestamp":1745425031000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000505094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,29]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,7,17]]},"published-print":{"date-parts":[[2020,7,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000505094","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,29]]}}}