{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:51:13Z","timestamp":1778885473966,"version":"3.51.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Dis"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Key pathogenetic mechanisms underlying renal disease progression are unaffected by current treatment. Metabolite profiling has significantly contributed to a deeper understanding of the biochemical metabolic networks and pathways in disease, but the biochemical details in maintenance hemodialysis (MHD) patients remain largely undefined. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The metabolic fingerprinting of plasma samples from 19 MHD patients and 12 healthy controls was characterized using liquid chromatography quadrupole time-of-flight mass spectrometry. Principal component analysis (PCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA) were applied to analyze the metabolic data. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The plasma metabolite profile distinguished the MHD patients from the healthy controls successfully by using both PCA and OPLS-DA models. Sixty-three metabolites were identified as the key metabolites to discriminate the MHD patients from healthy controls, involving several metabolic pathways (all &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). An increase in plasma levels of D-glucose, hippuric acid, androsterone glucuronide, indolelactic acid, and a reduction in plasma levels of glycerophosphocholine, serotonin, L-lactic acid, phytosphingosine, and several lysophosphatidylcholine were observed in MHD patients compared to healthy subjects. Metabolomics analysis combined with KEGG pathway enrichment analysis revealed that non-alcoholic fatty liver disease, choline metabolism in cancer, the forkhead box O signaling pathway, and the hypoxia-inducible factor-1 signaling pathway in MHD patients were significantly changed (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The identification of a novel signaling pathway and key metabolite markers in MHD patients provides insights into potential pathogenesis and valuable pharmacological targets for end-stage renal disease.<\/jats:p>","DOI":"10.1159\/000505156","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T22:00:35Z","timestamp":1581112835000},"page":"125-134","source":"Crossref","is-referenced-by-count":7,"title":["Plasma Metabolomics Profiling in Maintenance Hemodialysis Patients Based on Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry"],"prefix":"10.1159","volume":"6","author":[{"given":"Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianying","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00099.2005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32830d5bfa"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000019900.87535.43"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)81075-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62459-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/004982599238047"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013713905833"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009111132"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.113"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013020126"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2307"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1021\/ac051312t"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.9.5804"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00071.2006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901713"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813599"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.05.020"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016121362"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI122256"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12701"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001680"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-1182"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000048"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000355808"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb12095.x"}],"container-title":["Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:17:43Z","timestamp":1745425063000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000505156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,3,12]]},"published-print":{"date-parts":[[2020,4,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000505156","archive":["Portico"],"relation":{},"ISSN":["2296-9381","2296-9357"],"issn-type":[{"value":"2296-9381","type":"print"},{"value":"2296-9357","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}