{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:41:07Z","timestamp":1780731667057,"version":"3.54.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction:<\/i><\/b> Peak systolic velocity (PSV) of the middle cerebral artery (MCA) shows 100% sensitivity for predicting fetal anemia before the first intrauterine transfusion (IUT). However, its ability to predict subsequent transfusions has remained mostly controversial. <b><i>Objectives:<\/i><\/b> To assess if there is a need to change the threshold of MCA-PSV from 1.5 to 1.69 multiples of the median (MoM) to predict fetal anemia and the need for subsequent IUT. <b><i>Methods:<\/i><\/b> This is a retrospective audit, wherein case records of mothers who underwent IUT at the Bangalore Fetal Medicine Centre between April 2008 and May 2017 were reviewed; 86 cases were included, and the data were analyzed using MS Excel. The MCA-PSV and pretransfusion Hb were converted into MoM. 40 fetuses that had more than 1 IUT were included in the analysis. \u00ad<b><i>Results:<\/i><\/b> 31\/40 fetuses that had &#x3e;1 IUT had an MCA-PSV &#x3e;1.5 MoM, of which 29 were anemic according to the post-IUT Hb MoM. 20\/29 (69%) had an MCA-PSV &#x3e;1.69, whereas 9\/29 (31%) had an MCA-PSV between 1.5 and 1.69 MoM. Our study shows that changing the MCA-PSV threshold from 1.5 to 1.69 MoM will reduce the detection of fetal anemia and hence the need for repeat IUT by 31%. <b><i>Conclusions:<\/i><\/b> Increasing the fetal MCA-PSV threshold from 1.5 to 1.69 will miss out one-third of the fetuses that will require a 2nd, 3rd, or 4th IUT. This is more relevant in geographical areas where the parents must travel long distances for IUTs, which are performed in tertiary fetal care centers.<\/jats:p>","DOI":"10.1159\/000505398","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T22:00:41Z","timestamp":1581458441000},"page":"491-496","source":"Crossref","is-referenced-by-count":2,"title":["Prediction of Fetal Anemia in Subsequent Transfusions: Is There a Need to Change the Threshold of the Peak Systolic Velocity of the Middle Cerebral Artery?"],"prefix":"10.1159","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-4152","authenticated-orcid":false,"given":"Prathima","family":"Radhakrishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailaja","family":"Venkataravanappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reeth","family":"Sahana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anitha","family":"Shettikeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.01.059"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91896-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.04.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.10.788"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91317-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420102"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01314.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052855"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420102"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.118161"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.06.078"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.03.060"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00501-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14772"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13980"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18807"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1882"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:38:20Z","timestamp":1745422700000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000505398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,18]]},"published-print":{"date-parts":[[2020,6,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000505398","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}