{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:21:45Z","timestamp":1792844505293,"version":"4.5.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objectives:<\/i><\/b> Major depression is a highly prevalent disorder that causes economic burden in office workers. We conducted a randomized, double-blind, sham-controlled trial to evaluate the efficacy and safety of deep transcranial magnetic stimulation (dTMS) in office workers with treatment-resistant depression. <b><i>Methods:<\/i><\/b> In this study, we randomized office workers taking administrative leave for treatment-resistant major depressive disorder or bipolar disorder with current major depressive episode. dTMS treatment was applied at 120% resting motor threshold with 18 Hz over the left dorsolateral prefrontal cortex. The treatment sessions delivered a total of 1,980 pulses a day, 5 days a week, for 4\u20136 weeks. The primary outcome was change in the total score on the 21-item Hamilton Depression Rating Scale (HDRS-21) from baseline to the end of study in an intent-to-treat analysis. The secondary outcomes were the response and remission rates. We also assessed changes in cognitive function and adverse events. <b><i>Results:<\/i><\/b> Forty patients were randomized to active or sham dTMS groups (1:1). The change in the total score on the HDRS-21 was more significantly improved in the active group than in the sham group at 6 weeks (<i>p<\/i> = 0.045). There were no significant differences in the response and remission rates or cognitive measures between the active and sham groups. No serious adverse events were observed in either group. <b><i>Conclusions:<\/i><\/b> These results suggest that dTMS might be effective and safe in office workers with treatment-resistant depression. Further well-designed studies are needed.<\/jats:p>","DOI":"10.1159\/000505405","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T22:00:34Z","timestamp":1579298434000},"page":"208-213","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy and Safety of Deep Transcranial Magnetic Stimulation in Office Workers with Treatment-Resistant Depression: A Randomized, Double-Blind, Sham-Controlled Trial"],"prefix":"10.1159","volume":"79","author":[{"given":"Yuki","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Kito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Shigeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3095"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61340-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.5.513"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.10.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.11.1905"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2008.20.1.74"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2010.02183.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20300"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04872gre"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31802fa393"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000455"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3791\/55100"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60368-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.26"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2009.08.002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.08.033"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/da.22658"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.04.022"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:38:33Z","timestamp":1745422713000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000505405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,4,16]]},"published-print":{"date-parts":[[2020,4,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000505405","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}