{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:55:31Z","timestamp":1785192931928,"version":"3.55.0"},"reference-count":32,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; For selected patients with severe emphysema, bronchoscopic lung volume reduction with endobronchial valves (EBV) is recognized as an additional treatment option. In most trials investigating EBV treatment, patients with a very low diffusing capacity (DLCO) were excluded from participation. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; Our goal was to investigate whether EBV treatment in patients with emphysema with a very low DLCO is safe and effective. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This was a single-center retrospective analysis including patients with emphysema and a DLCO \u226420%pred who underwent EBV treatment. Follow-up was performed 6 months post-treatment. Outcome parameters were compared to a historical matched control group (DLCO &amp;#x3e;20%pred, matched for sex, age, forced expiratory volume in 1 s [FEV&lt;sub&gt;1&lt;\/sub&gt;], and residual volume [RV]). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Twenty patients (80% female, 64 \u00b1 6 years, FEV&lt;sub&gt;1&lt;\/sub&gt; 26 \u00b1 6%pred, RV 233 \u00b1 45%pred, DLCO 18 \u00b1 1.6%pred) underwent EBV treatment. At 6 months follow-up, we found a statistically significant improvement in FEV&lt;sub&gt;1&lt;\/sub&gt; (0.08 \u00b1 0.12 L), RV (\u20130.45 \u00b1 0.95 L), 6-min walking distance (38 \u00b1 65 m), and St. George\u2019s Respiratory Questionnaire (\u201312 \u00b1 13 points). With the exception of FEV&lt;sub&gt;1&lt;\/sub&gt;, all exceeded the minimal clinically important difference. The most common serious adverse event was a pneumothorax requiring intervention (15%). There were no significant differences in outcome compared to the DLCO &amp;#x3e;20%pred control group. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In this single-center retrospective analysis, we showed statistically significant and clinically relevant improvements in lung function, exercise capacity, and quality of life up to 6 months after EBV treatment in emphysema patients with a DLCO \u226420% (14\u201320%) of predicted with no increased risk of serious adverse events.<\/jats:p>","DOI":"10.1159\/000505428","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T22:00:34Z","timestamp":1579644034000},"page":"163-170","source":"Crossref","is-referenced-by-count":21,"title":["Endobronchial Valve Treatment in Emphysema Patients with a Very Low DLCO"],"prefix":"10.1159","volume":"99","author":[{"given":"Marlies","family":"van\u00a0Dijk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-9673","authenticated-orcid":false,"given":"Jorine\u00a0E.","family":"Hartman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Klooster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick\u00a0H.T.","family":"Ten\u00a0Hacken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huib\u00a0A.M.","family":"Kerstjens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9555-3422","authenticated-orcid":false,"given":"Dirk-Jan","family":"Slebos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000146"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00164-2019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000496122"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201803-0590OC"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60001-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201707-1327OC"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507807"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201607-1383OC"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa11798"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030287"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.09.006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030492"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.6.1321"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000453588"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200053377"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00219111"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00063810"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200050513"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00535-2015"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30431-4"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00146012"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.5.1394"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.09.004"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000452629"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159\/000448761"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2003.08.004"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.01.010"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2004.12.001"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-7-18"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:38:51Z","timestamp":1745422731000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000505428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,14]]},"published-print":{"date-parts":[[2020,2,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000505428","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}