{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:51:13Z","timestamp":1790844673743,"version":"4.1.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Care"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Prophylactic mastectomy is an effective approach to breast cancer risk reduction in patients at high risk. Further studies using standardized measures for quality of life are needed to better understand the effect of prophylactic mastectomy on individual patients and, thereby, allow for better patient counseling and selection. <b><i>Methods:<\/i><\/b> In this prospective study patients undergoing bilateral mastectomy were asked to complete the BREAST-Q questionnaire before and 1 year after surgery. All patients underwent bilateral mastectomy with implant-based breast reconstruction. Patient- and surgery-related information was collected in a database. <b><i>Results:<\/i><\/b> In total, 48 patients underwent bilateral skin-sparing mastectomy. Of these, 29 (60.4%) suffered from breast cancer. A 2-stage reconstruction with intermediate expander implantation was conducted in 19 (39.6%) patients. All patients completed the BREAST-Q questionnaire. The domain \u201cpsychosocial well-being\u201d was significantly improved from a mean score of 74.98 preoperatively to a postoperative score of 81.56 (<i>p<\/i> = 0.021). In contrast, the domain \u201cphysical well-being\u201d dropped \u20138.38 points on average to a postoperative score of 74.96 (<i>p<\/i> &#x3c; 0.001). Interestingly, patients with the lowest preoperative score in the domain \u201csatisfaction with breast\u201d showed the greatest increase after surgery (50.31 vs. 67.25, <i>p<\/i> &#x3c; 0.001). On the contrary, patients with the highest preoperative values experienced the strongest decrease in satisfaction (91.60 vs. 75.27, <i>p<\/i> = 0.012). <b><i>Conclusion:<\/i><\/b> Implant-based prophylactic mastectomy leads to good quality-of-life results in patients at high risk for breast cancer. Especially, patients with a low preoperative satisfaction with their breasts have a significantly higher chance of experiencing substantial improvements in their quality of life.<\/jats:p>","DOI":"10.1159\/000505449","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T17:00:32Z","timestamp":1579885232000},"page":"519-526","source":"Crossref","is-referenced-by-count":16,"title":["Quality of Life after Bilateral and Contralateral Prophylactic Mastectomy with Implant Reconstruction"],"prefix":"10.1159","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-4366","authenticated-orcid":false,"given":"R\u00fcdiger","family":"Klapdor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Wei\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elna","family":"Kuehnle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Kohls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"von\u00a0Ehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Philippeit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Hille-Betz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1465"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1086\/375033"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303829"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.9568"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.3.319"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9206-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-012-9588-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-5915-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-015-1181-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6585-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2018.02.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181aee807"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318290f8a0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2012.10.015"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181e3b38a"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3181a0cfee"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2016.06.010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-015-1435-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01329.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.37.2.243"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002748.pub4"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318177415e"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2007.00521.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.233"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.9901"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1611(200011\/12)9:6<473::AID-PON490>3.0.CO;2-T"}],"container-title":["Breast Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:39:10Z","timestamp":1745408350000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000505449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,10,20]]},"published-print":{"date-parts":[[2020,11,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000505449","archive":["Portico"],"relation":{},"ISSN":["1661-3791","1661-3805"],"issn-type":[{"value":"1661-3791","type":"print"},{"value":"1661-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}