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Biopsy revealed a sclerosing signet ring cell carcinoma with histopathologic features mimicking those of a primary signet ring cell (histiocytoid) carcinoma of the eyelid of eccrine or apocrine gland origin, a metastasis from an invasive lobular breast carcinoma or a metastatic diffuse-type gastric carcinoma. An extensive panel of immunohistochemical stains and molecular genetic analyses unequivocally failed to establish a precise diagnosis. Electron microscopy demonstrated features of a primary lacrimal gland lesion with intracytoplasmic lumens and zymogen granules typical of lacrimal secretory pyramidal cells. A thorough initial systemic work-up failed to reveal a primary visceral malignancy. Fifteen months of follow-up have failed to detect the emergence of another primary malignancy. To the best of our knowledge, a tumor with the morphology of the current lesion has not been previously described in the major or accessory lacrimal glands.<\/jats:p>","DOI":"10.1159\/000505490","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T22:00:35Z","timestamp":1581112835000},"page":"265-274","source":"Crossref","is-referenced-by-count":5,"title":["Sclerosing Signet Ring Cell Carcinoma of the Lacrimal Gland: A Potentially New Primary 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