{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T09:44:40Z","timestamp":1750239880139,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>Tumor necrosis factor alpha (TNF-\u03b1) has been associated with the pathogenesis of several autoimmune diseases. Also, various studies in different ethnics showed an association between TNF-\u03b1 gene polymorphisms and susceptibility to vitiligo. The paucity of genetic data led us to undertake this study to evaluate the association of five TNF-\u03b1 SNPs (rs1799964, rs1800630, rs1799724, rs1800629, and rs361525) with the development of vitiligo in South Indian Tamils. A total of 264 vitiligo patients and 264 healthy controls were recruited and TNF-\u03b1 genotyping was performed using amplification-refractory mutation system polymerase chain reaction and TaqMan allele discrimination assay. Circulatory TNF-\u03b1 levels were measured by enzyme-linked immunosorbent assay. We observed that a single polymorphic allele A in the promoter region -308 (rs1800629) conferred significant risk to develop vitiligo (&lt;i&gt;p&lt;\/i&gt; = 0.0002, OR = 1.70, 95% CI = 1.28\u20132.25), whereas the other polymorphisms failed to contribute to disease risk (&lt;i&gt;p&lt;\/i&gt; &amp;#x3e; 0.05). From the constructed haplotypes, TCCAG was found to be a significant risk factor for vitiligo (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). Also, a strong linkage disequilibrium was observed between the following SNPs: (1) rs1799964 and rs1800629 (2) rs1800630 and rs1799724 (D\u2019 = 0.90). Analysis of the influence of genotype on phenotypes revealed that the A allele of rs361525 was a risk factor for vitiligo in females (&lt;i&gt;p&lt;\/i&gt; = 0.04, OR = 0.45, 95% CI = 0.21\u20130.95), whilst the rs1800629 allele conferred protection against early disease onset (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). A statistically significant difference in plasma TNF-\u03b1 levels was found between cases and controls (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). The TNF-\u03b1 -308A allele and TCCAG haplotype were identified as genetic risk factors for vitiligo susceptibility in South Indian Tamils.<\/jats:p>","DOI":"10.1159\/000505544","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T22:00:57Z","timestamp":1582149657000},"page":"554-564","source":"Crossref","is-referenced-by-count":8,"title":["Association Analysis of Tumor Necrosis Factor Alpha Promoter Polymorphisms and Vitiligo Susceptibility in South Indian Tamils"],"prefix":"10.1159","volume":"236","author":[{"given":"Kalai\u00a0Selvi","family":"Rajendiran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medha","family":"Rajappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laxmisha","family":"Chandrashekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devinder\u00a0Mohan","family":"Thappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panneer","family":"Devaraju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05377.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.45144"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.02.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00023.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.1o049.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/path.4188"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2550139.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0039-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2011.560913"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000112932"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.66.4.562"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.01.007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.3195"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2018.76225"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.02.027"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0037-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12147"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4238\/2013.July.8.1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0904-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.508"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-006-0664-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4238\/2015.December.16.30"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12866"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4238\/2015.May.25.6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.039164"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700822"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3892\/br.2017.908"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163806"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.1969.tb03496.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20038"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.92668"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2009.06.007"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(01)00322-6"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:40:25Z","timestamp":1745422825000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000505544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,11,13]]},"published-print":{"date-parts":[[2020,11,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000505544","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.11871045","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2020]]}}}