{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:02:07Z","timestamp":1788184927927,"version":"build-2803163510"},"reference-count":21,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background\/Objective:<\/i><\/b> In this study, we demonstrated the effects of obstructive sleep apnea syndrome (OSAS) on the prognosis of amyotrophic lateral sclerosis (ALS). However, the effects of sleep-related disorders other than breathing problems are still waiting to be delineated. <b><i>Methods:<\/i><\/b> In this longitudinal retrospective and prospective study, we investigated 73 patients with ALS compared to 20 healthy subjects, to determine sleep-related disorders and their impact on disease prognosis. <b><i>Results:<\/i><\/b> In patients with ALS, the mean respiratory disturbance index (RDI) was 28.0\/h, which was significantly higher than that in the controls (<i>p<\/i> &#x3c; 0.001). OSAS was present in 67% of the patients, sleep-related hypoxemia was observed in 13.7% of the patients, and 5.4% had central sleep apnea syndrome. In patients with bulbar-onset disease, higher RDI was almost significantly associated with lower survival (<i>p<\/i> = 0.056). The mean index of periodic leg movements in sleep was significantly higher in patients with ALS (34.0 \u00b1 19.9\/h) than that in the controls (12.5 \u00b1 15.5\/h; <i>p<\/i> &#x3c; 0.001). Periodic leg movements disorder (PLMD) was diagnosed in 23 patients with ALS (31.5%); fragmentary myoclonus was present in 13.7% of patients, and REM-sleep behavior disorder was diagnosed in 4 patients (5.4%). The presence of PLMD in addition to OSAS was significantly associated with worse prognosis and poorer survival (<i>p<\/i> = 0.040). <b><i>Conclusions:<\/i><\/b> These findings emphasize that sleep-related disorders other than OSAS deserve attention in ALS. ALS is a catastrophic and frustrating disease for both patients and physicians; thus, the diagnosis and treatment of comorbid sleep disorders could improve the survival of patients with ALS.<\/jats:p>","DOI":"10.1159\/000505575","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T22:00:33Z","timestamp":1582927233000},"page":"148-154","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Sleep-Related Disorders on the Prognosis of Amyotrophic Lateral Sclerosis"],"prefix":"10.1159","volume":"19","author":[{"given":"Aylin","family":"Reyhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulcin","family":"Benbir\u00a0Senel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Karadeniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22629"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.4704"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23261"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.228007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12593"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2011.557736"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00735"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1590\/S1679-45082012000400006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00210-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0000000000000234"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316515"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.10.2000"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.01934.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.01.001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003156"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03673.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.6016"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13156"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:40:38Z","timestamp":1745422838000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000505575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":21,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2020,5,14]]},"published-print":{"date-parts":[[2020,5,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000505575","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}