{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:54:54Z","timestamp":1761630894935,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> There are no evidence-based recommendations for performing upper gastrointestinal endoscopy (UGIE) in patients with extra-oesophageal symptoms of gastro-oesophageal reflux disease (GORD). However, UGIEs are often performed in clinical practice in these patients. We aimed to assess the prevalence of gastro-oesophageal lesions in patients with atypical GORD symptoms. <b><i>Methods:<\/i><\/b> Patients complaining of at least one extra-oesophageal GORD symptom and undergoing UGIE in seven centres were prospectively enrolled. Clinically relevant lesions (Barrett\u2019s oesophagus, erosive oesophagitis, gastric precancerous conditions, peptic ulcer, cancer, and <i>H. pylori<\/i> infection) were statistically compared between groups regarding GORD symptoms (atypical vs. both typical and atypical), type of atypical symptoms, age, and presence of hiatal hernia. <b><i>Results:<\/i><\/b> Two hundred eleven patients were enrolled (male\/female: 74\/137; mean age: 55.5 \u00b1 14.7 years). Barrett\u2019s oesophagus was detected in 4 (1.9%), erosive oesophagitis in 12 (5.7%), gastric precancerous conditions in 22 (10.4%), and <i>H. pylori<\/i> infection in 38 (18%) patients. Prevalence of clinically relevant lesions was lower in patients with only atypical GORD symptoms (28.6 vs. 42.5%; <i>p<\/i> = 0.046; \u03c7<sup>2<\/sup> test), in patients \u226450 years (20 vs. 44.8%; <i>p<\/i> = 0.004; \u03c7<sup>2<\/sup> test), and in those in ongoing proton pump inhibitor (PPI) therapy (21.1 vs. 40.2%; <i>p<\/i> = 0.01; \u03c7<sup>2<\/sup> test). No clinically relevant lesions were detected in patients \u226450 years, without alarm symptoms, and receiving PPI therapy. Hiatal hernia was diagnosed in only 6 patients with cardiologic and in 41 patients with ear-nose-throat symptoms (11.3 vs. 35.1%; <i>p<\/i> = 0.03; \u03c7<sup>2<\/sup> test). <b><i>Conclusions:<\/i><\/b> Clinically relevant lesions are uncommon among young (\u226450 years) patients with extra-oesophageal GORD symptoms. Hiatal hernia is not more prevalent in patients with cardiologic symptoms and suspicion of GORD. The usefulness of UGIE in these patients is questionable.<\/jats:p>","DOI":"10.1159\/000505581","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T22:00:31Z","timestamp":1580853631000},"page":"312-317","source":"Crossref","is-referenced-by-count":4,"title":["Upper Endoscopy in Patients with Extra-Oesophageal Reflux Symptoms: A Multicentre Study"],"prefix":"10.1159","volume":"27","author":[{"given":"Angelo","family":"Zullo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Fiorini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrio","family":"Bassotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bachetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Monica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Macor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omero\u00a0Alessandro","family":"Paoluzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Scaccianoce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"De\u00a0Francesco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Lorenzetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria\u00a0Maria","family":"Saracino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Pavoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dino","family":"Vaira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314109"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.02.019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i17.2045"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.05.016"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.444"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0101-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04581.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.02.001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.322"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6154"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.02.030"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2018.11.029"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12149"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.08.010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.4.464"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S136036"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i28.9592"}],"container-title":["GE - 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