{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:43:27Z","timestamp":1792701807525,"version":"4.5.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction:<\/i><\/b> Platelets play a fundamental role in the pathogenesis of acute coronary syndrome (ACS). The platelet count (PC) at hospital admission is easy to obtain, but whether thrombocytopenia or\/and thrombocytosis impact long-term mortality (LTM) after ACS is unclear. <b><i>Objective:<\/i><\/b> To evaluate the effect of PC at hospital admission on LTM in patients with ACS. <b><i>Methods:<\/i><\/b> This retrospective cohort study included patients with the ICD-10 codes for unstable angina (I.20) and acute myocardial infarction (I.21, I.22). Thrombocytopenia was defined as a blood PC &#x3c;150 G\/L and thrombocytosis as a PC &#x3e;450 G\/L. Additional platelet indices which were tested included plateletcrit (PCT), the mean platelet volume (MPV), the platelet distribution width (PDW), and the platelet larger cell ratio (P-LCR). Data on all-cause death were obtained from the National Health Fund database. <b><i>Results:<\/i><\/b> The study included 3,162 patients with a median follow-up of 27.2 months (interquartile range 12.5\u201346.8 months; max 68.7 months). Patients with thrombocytopenia and thrombocytosis yielded a higher maximal analyzed 5-year mortality rate in comparison with normal PC patients (45.8 and 47.7 vs. 24.2%, respectively; <i>p<\/i> &#x3c; 0.00001) which was mainly driven by higher deaths at 1\u20132 years after ACS. The 5-year LTM was also significantly higher in patients with abnormal PCT and MPV levels in comparison with patients with PCT and MPV within the normal range. Other platelet indices (PDW, P-LCR) were not associated with a worse outcome. The Cox proportional hazards model revealed that thrombocytopenia at admission was independently associated with higher LTM after ACS (RR 1.83; 95% CI 1.1\u20133.0; <i>p<\/i> = 0.01). <b><i>Conclusions:<\/i><\/b> Both thrombocytopenia and thrombocytosis at hospital admission in post-ACS patients are associated with a significant almost two times higher 5-year mortality rate.<\/jats:p>","DOI":"10.1159\/000505640","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T22:00:31Z","timestamp":1580853631000},"page":"148-154","source":"Crossref","is-referenced-by-count":18,"title":["Blood Platelet Count at Hospital Admission Impacts Long-Term Mortality in Patients with Acute Coronary Syndrome"],"prefix":"10.1159","volume":"145","author":[{"given":"Artur","family":"Ma\u0142yszczak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"\u0141ukawska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Dyl\u0105g","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weronika","family":"Lis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Mysiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiktor","family":"Kuliczkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-40673"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0707"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3041565"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2019.04.003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.11909\/j.issn.1671-5411.2018.05.004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.01.046"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.11.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.03.011"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.066"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000484"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.07.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.065"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.01.044"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000350"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001258"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.05.037"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505640","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:41:17Z","timestamp":1745422877000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000505640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,13]]},"published-print":{"date-parts":[[2020,3,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000505640","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}