{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T13:44:56Z","timestamp":1771854296866,"version":"3.50.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Referral to weight loss programmes is the only effective treatment for non-alcoholic fatty liver disease (NAFLD). Clinicians should advise weight loss and screen for liver fibrosis using the Enhanced Liver Fibrosis (ELF) score. <b><i>Aim:<\/i><\/b> To examine if the ELF score changes with weight loss. <b><i>Design and Setting:<\/i><\/b> Randomised controlled trial (ISRCTN85485463) in UK primary care during 2007\u20132008. <b><i>Method:<\/i><\/b> Adults with a BMI of 27\u201335 kg\/m<sup>2<\/sup> and \u22651 risk factor for obesity-related disease were randomised to attend a community weight loss programme (<i>n<\/i> = 45) or receive usual weight loss advice from a practice nurse (<i>n<\/i> = 28). Weight and the ELF score were measured at baseline and 1 year. Analysis of covariance examined mean changes in the ELF score between groups and its relationship with weight loss. <b><i>Results:<\/i><\/b> Mean (SD) BMI was 31.10 kg\/m<sup>2<\/sup> (2.55) with evidence of moderate levels of liver fibrosis at baseline (mean ELF score: 8.93 [0.99]). There was no evidence that the community weight loss programme reduced the ELF score compared with usual care (difference +0.13 points, 95% CI: \u20130.25 to 0.52) despite greater weight loss (difference: \u20132.66 kg, 95% CI: \u20135.02 to \u20130.30). Mean weight loss in the whole cohort was 7.8% (5.9). There was no evidence of an association between weight change and change in ELF; the coefficient for a 5% weight loss was \u20130.15 (95% CI: \u20130.30 to 0.0002). <b><i>Conclusion:<\/i><\/b> We found no evidence that the ELF score changed meaningfully following moderate weight loss. Clinicians should not use the ELF score to measure improvements in NAFLD fibrosis following weight loss programmes.<\/jats:p>","DOI":"10.1159\/000505667","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T22:00:46Z","timestamp":1584741646000},"page":"144-151","source":"Crossref","is-referenced-by-count":4,"title":["The Effect of Moderate Weight Loss on a Non-Invasive Biomarker of Liver Fibrosis: A Randomised Controlled Trial"],"prefix":"10.1159","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1955-7234","authenticated-orcid":false,"given":"Dimitrios\u00a0A.","family":"Koutoukidis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan\u00a0A.","family":"Jebb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Aveyard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerys\u00a0M.","family":"Astbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.014"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28697"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i31.7006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.013"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.08.011"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61838-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27368"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i2.475"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21984"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619865133"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.03.033"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/457473"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00803-X"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2017-100806"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61344-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.016"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.005"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24376"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.2248"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.09.150"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw341"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.012"}],"container-title":["Obesity Facts"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/505667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:41:32Z","timestamp":1745422892000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000505667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,5,7]]},"published-print":{"date-parts":[[2020,4,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000505667","archive":["Portico"],"relation":{},"ISSN":["1662-4025","1662-4033"],"issn-type":[{"value":"1662-4025","type":"print"},{"value":"1662-4033","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}