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Moreover, it is a symptom situated at, more than any other pain condition, a crosspoint where several disciplines meet, for example, dentists; manual therapists; ophthalmologists; psychologists; and ear-nose-throat, pain, and internal medicine physicians besides neurologists and neurosurgeons. Recently, a new version of the most widely used classification system among neurologists for headache and facial pain, the International Classification of Headache Disorders, has been published. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aims of this study were to provide an overview of the most prevalent etiologies of facial pain and to provide a generic framework for the neurologist on how to manage patients presenting with facial pain. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; An overview of the different etiologies of facial pain is provided from the viewpoint of the respective clinical specialties that are confronted with facial pain. &lt;b&gt;&lt;i&gt;Key message:&lt;\/i&gt;&lt;\/b&gt; Caregivers should \u201cthink outside their own box\u201d and refer to other disciplines when indicated. If not, a correct diagnosis can be delayed and unnecessary treatments might be given. The presented framework is aimed at excluding life- or organ-threatening diseases, providing several clinical clues and indications for technical investigations, and ultimately leading to the correct diagnosis and\/or referral to other disciplines. <\/jats:p>","DOI":"10.1159\/000505727","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T22:00:50Z","timestamp":1585346450000},"page":"5-16","source":"Crossref","is-referenced-by-count":25,"title":["Facial Pain: A Comprehensive Review and Proposal for a Pragmatic Diagnostic Approach"],"prefix":"10.1159","volume":"83","author":[{"given":"Laura","family":"Van Deun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"de 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