{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:15:47Z","timestamp":1783448147265,"version":"3.55.0"},"reference-count":23,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":2132,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: The inflammatory microenvironment is closely related to the occurrence and development of cancer. Members of the interleukin-12 (IL-12) cytokine family play synergistic or antagonistic roles in the tumor microenvironment, in the form of classic heterodimers or newly discovered monomers or homodimers. Objective: The purpose of this study was to investigate the association between IL-12A and the clinicopathology and prognosis of differentiated thyroid cancer (DTC). Methods: A total of 101 pathologically confirmed DTC patients were included in this study. Immunohistochemistry was performed to assess IL-12A expression in DTC and corresponding paracancerous tissues. The associations of IL-12A with clinicopathology and prognosis were evaluated. Results: IL-12A was expressed in both normal thyroid tissues and DTC, but its expression level was significantly higher in DTC than in normal thyroid tissues (p &amp;lt; 0.001). IL-12A was positively correlated with tumor size (p = 0.027), risk stratification (p = 0.020), and TNM (Tumor-Node-Metastasis) stage (p = 0.024), but not with age, sex, pathological type, multifocality, extrathyroid extension, lymph node metastasis, and distant metastasis (all p &amp;gt; 0.05). Lymphocytic thyroiditis was found in 26\/101 patients (25.7%), which was negatively associated with IL-12A expression (p = 0.018). Multivariate logistic regression analysis showed that risk stratification was the significant independent predictor of IL-12A expression. The rate of disease persistence or recurrence (P&amp;R) was 13\/101 (12.9%), and a positive relationship was found between IL-12A expression and P&amp;R (p = 0.020). Disease-free survival was affected by factors such as tumor size, extrathyroid extension, tumor stage (T stage), and IL-12A expression, with p values of 0.006, 0.048, 0.002, and 0.012, respectively. Multivariate Cox proportional-hazards analysis showed that tumor size \u22652 cm (hazard ratio [HR] = 4.041 [95% CI: 1.144\u201314.274], p = 0.031) and high IL-12A expression (HR = 4.027 [95% CI 1.014\u201315.994], p = 0.049) were independent predictors of prognosis of DTC patients. Conclusions: IL-12A is highly expressed in DTC and is associated with disease aggressiveness. In addition, IL-12A is an independent predictor of the outcome of DTC.<\/jats:p>","DOI":"10.1159\/000505811","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T17:00:31Z","timestamp":1587142831000},"page":"139-147","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":4,"title":["High Expression of Interleukin-12A and Its Association with the Clinicopathology and Prognosis of Differentiated Thyroid Cancer"],"prefix":"10.1530","volume":"9","author":[{"given":"Guo-Qiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Tian","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Ling","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Yong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"issue":"1","key":"2026070713010358400_ref1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.bbrc.2019.04.119","article-title":"The prognostic potential of alpha-1 type I collagen expression in papillary thyroid cancer","volume":"515","author":"Huang","year":"2019","journal-title":"Biochem Biophys Res Commun","ISSN":"https:\/\/id.crossref.org\/issn\/0006-291X","issn-type":"print"},{"issue":"6","key":"2026070713010358400_ref2","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.21873\/anticanres.13409","article-title":"IGF-IEc Expression Is Associated With Advanced Differentiated Thyroid Cancer","volume":"39","author":"Karagiannis","year":"2019","journal-title":"Anticancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/0250-7005","issn-type":"print"},{"key":"2026070713010358400_ref3","doi-asserted-by":"crossref","unstructured":"Haugen\n              BR\n            , AlexanderEK, BibleKC, DohertyGM, MandelSJ, NikiforovYE, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. 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